Many liver diseases share a common characteristic: fibrosis, the progressive accumulation of scarring in the liver tissue. Those scars—the liver's response to persistent injuries or attacks—can prevent the organ from functioning ...
Apr 28, 2026
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Adding bile acids as farnesoid X receptor agonists to the culture medium supported the growth and development of unique stem cell-derived hepatic organoids, report researchers from Japan. These three-dimensional liver organoids ...
Jul 7, 2025
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Microbes living in our guts help us digest food by reshaping the bile acids that our livers produce for breaking down fats. It turns out that two of these microbially-modified bile acids may affect our risk—in opposite directions—for ...
Dec 16, 2024
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Peking University-led researchers have modified an existing treatment for liver disease that does not cause itchiness, a common side effect of existing treatments.
A study published in the journal Protein & Cell details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis ...
Aug 23, 2024
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Removing a nuclear bile acid receptor that regulates glucose and lipid stability from the intestine blocks gut inflammation in mice, according to researchers at Children's Hospital Los Angeles. Their findings are published ...
Aug 15, 2024
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Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process.
Nov 13, 2023
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The prevalence of colorectal cancer in people under the age of 50 has risen in recent decades. One suspected reason: the increasing rate of obesity and high-fat diets.
Aug 22, 2023
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Clinical evidence suggests that elderly individuals are at a higher risk of contracting viral infections. Quite notably, the older people also have lower mean body temperatures. However, the effects of increased body temperature ...
Jul 20, 2023
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SARS-CoV-2, the virus that causes COVID-19, attaches to a cellular receptor called angiotensin-converting enzyme 2 (ACE2), and activation of the farnesoid X receptor increases ACE2 expression. New research published in the ...
Apr 5, 2023
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