Oncology & Cancer

Gene-targeted cancer drugs, slow release overcome resistance

Biomedical engineers at Duke University have developed a method to address failures in a promising anti-cancer drug, bringing together tools from genome engineering, protein engineering and biomaterials science to improve ...

Oncology & Cancer

Obesity and psychosocial well-being among patients with cancer

In a study published in Psycho-Oncology, excess weight was linked with poorer psychosocial health among older adults diagnosed with breast cancer or prostate cancer. The association was not seen in older patients with colon ...

Oncology & Cancer

Protein's role in inflammation-related cancer studied

It's well established that chronic inflammation can lead to colon cancer, but the molecular mechanisms behind this association aren't fully understood. Research at Vanderbilt University Medical Center into the role that the ...

Oncology & Cancer

Antibiotic use linked to heightened bowel cancer risk

Antibiotic use (pills/capsules) is linked to a heightened risk of bowel (colon) cancer, but a lower risk of rectal cancer, and depends, to some extent, on the type and class of drug prescribed, suggests research published ...

Medications

PET imaging shows if PD-1 cancer immunotherapy is working

PD-1 is a protein on our T cells that normally keeps these immune cells from running amok. A growing number of cancer drugs are designed to inhibit PD-1, enabling patients' T-cells to attack and kill cancerous cells. PD-1 ...

Oncology & Cancer

Exposing how pancreatic cancer does its dirty work

Pancreatic cancer is one of the most insidious forms of the disease, in which an average of only 9% of patients are alive five years after diagnosis. One of the reasons for such a dismal outcome is that pancreatic cancer ...

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Colorectal cancer, commonly known as bowel cancer, is a cancer from uncontrolled cell growth in the colon, rectum, or appendix. Symptoms typically include rectal bleeding and anemia which are sometimes associated with weight loss and changes in bowel habits.

Most colorectal cancer occurs due to lifestyle and increasing age with only a minority of cases associated with underlying genetic disorders. It typically starts in the lining of the bowel and if left untreated, can grow into the muscle layers underneath, and then through the bowel wall. Screening is effective at decreasing the chance of dying from colorectal cancer and is recommended starting at the age of 50 and continuing until a person is 75 years old. Localized bowel cancer is usually diagnosed through sigmoidoscopy or colonoscopy.

Cancers that are confined within the wall of the colon are often curable with surgery while cancer that has spread widely around the body is usually not curable and management then focuses on extending the person's life via chemotherapy and improving quality of life. Colorectal cancer is the fourth most commonly diagnosed cancer in the world, but it is more common in developed countries. Around 60% of cases were diagnosed in the developed world. It is estimated that worldwide, in 2008, 1.23 million new cases of colorectal cancer were clinically diagnosed, and that it killed 608,000 people.

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