Gastroenterology

Colonic gene mapping gives insights into intestinal diseases

Using a technique called spatial transcriptomics, researchers at Karolinska Institutet have analyzed the gene expression in the mouse colon and created a map showing where in the tissue individual genes are expressed. When ...

Medical research

Your microbiome shapes your life, but where did it come from?

The gut microbiome is an ecosystem of hundreds to thousands of microbial species living within the human body. These populations affect our health, fertility, and even our longevity. But how do they get there in the first ...

Gastroenterology

Can we harness intestinal cells to treat endocrine disorders?

Enteroendocrine cells punch above their weight. Constituting just about 1 percent of intestinal cells, they produce, as a group, around 15 different hormones. These not only regulate intestinal function and digestion, but ...

Immunology

Cause of inflammatory bowel disease discovered

Chronic inflammatory bowel disease (IBD) is becoming increasingly widespread. Until now, however, the underlying causes of the inflammation responses were unclear. Scientists at the Technical University of Munich (TUM) have ...

Inflammatory disorders

Scientists reveal mechanism for colon pain and inflammation

Researchers at the NYU Pain Research Center have identified a mechanism that underlies inflammation and pain in the colon, and demonstrated that blocking a key receptor from entering colon cells can inhibit inflammation and ...

Medical research

Stool samples reveal microbial enzyme driving bowel disease

Ulcerative colitis, a subtype of inflammatory bowel disease, is a chronic ailment of the colon affecting nearly one million individuals in the United States. It is thought to be linked to disruptions in the gut microbiome—the ...

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