Forty years after researchers first discovered it in fruit flies, a once-obscure cluster of proteins called PRC2 has become a key target for new cancer-fighting drugs, due to its tendency—when mutated—to bind to and silence ...
Jun 15, 2018
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Researchers at University of California, San Diego School of Medicine have discovered a self-regulating loop in the Hippo pathway, a signaling channel garnering increased attention from cancer researchers due to its role ...
Jun 26, 2015
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(Medical Xpress) -- A study published in Genes and Development from scientists at the Friedrich Miescher Institute for Biomedical Research pinpoints the importance of maternal epigenetic influences during early embryogenesis ...
May 7, 2012
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Melbourne scientists have discovered how tumour development is driven by mutations in the most important gene in preventing cancer, p53.
Nov 7, 2018
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Investigators who previously developed a recipe for turning skin cells into primitive muscle-like cells that can be maintained indefinitely in the lab without losing the potential to become mature muscle have now uncovered ...
Aug 19, 2021
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A human genetic mechanism hijacked by SARS-CoV-2, the coronavirus behind the COVID-19 pandemic, to help it spread also makes it vulnerable to a new class of drug candidates, a new study finds.
Jun 24, 2021
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A signaling pathway in fat cells may one day provide the key to better treatments for obesity, according to new research by scientists in the Perelman School of Medicine at the University of Pennsylvania. They reported their ...
Dec 6, 2016
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When brains begin developing, there are a lot of moving parts—and when mutations happen in early neurodevelopment, it can lead to disorders like macrocephaly and autism. But scientists don't know much about the ways that ...
Mar 11, 2020
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White adipose tissue stores excess calories as fat that can be released for use in other organs during fasting. Mammals also have small amounts of brown adipose tissue, which primarily acts as an effective fat burner for ...
Dec 13, 2014
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The primary cause of death from breast cancer is the spread of tumor cells from the breast to other organs in the body. Northwestern Medicine® scientists have discovered a new pathway that can stop breast cancer cells from ...
Jun 3, 2014
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