MeSH tree: D12.776.543.585.400
Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems—prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, ...
Apr 9, 2024
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How does one distinguish the smoothness of silk or the coarse texture of sandpaper? Individuals' sense of touch is complex, requiring circuits in the brain to process incoming information much like a computer. These circuits ...
Mar 7, 2024
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A surge of a neural-specific protein in the brain is the earliest-yet biomarker for Alzheimer's disease, report University of Illinois Urbana-Champaign researchers studying a mouse model of the disease. Furthermore, the increased ...
Mar 5, 2024
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Studies at MIT and elsewhere are producing mounting evidence that light flickering and sound clicking at the gamma brain rhythm frequency of 40 Hz can reduce Alzheimer's disease (AD) progression and treat symptoms in human ...
Feb 28, 2024
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A research team led by Prof. Dr. Hilmar Bading, neurobiologist at Heidelberg University, examined a neuroprotective molecule that belongs to a novel drug class. It is able to inhibit the interactions of certain proteins and ...
Feb 8, 2024
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Calcium ions are essential for cells, but can be toxic in higher concentrations. A team of researchers has now designed and prepared a combination drug that kills tumor cells by modulating the calcium influx into the cell. ...
Jan 29, 2024
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Cornell researchers have created a genetically engineered mouse model that could shed light on the causes of human infertility and allow researchers to explore other areas of reproduction.
Jan 18, 2024
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The activity of neurons in the mammalian brain has been found to be linked with various physiological processes, including the flow of blood that provides them with the energy required to function (i.e., cerebral blood flow). ...
A new study, published in Cell Reports, reports a novel mechanism behind dysregulated neuronal activity, a key pathology of amyotrophic lateral sclerosis (ALS). Researchers at King's College London found that molecular, structural, ...
Nov 30, 2023
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Researchers at Zhejiang University, China, have explored mechanisms for the sustained antidepressant effects of ketamine, suggesting that a direct N-methyl-D-aspartate receptor (NMDAR) blockade might play a role.
