MeSH tree: A11.561
Researchers from the Roger Williams Institute of Liver Studies at King's College London developed two 3D models from human tissue to understand the effects that a drug—a cyclophilin inhibitor—has on liver tissue damaged by ...
Aug 21, 2025
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14
Cholesterol plays a vital role in the body, providing structural support to cells and serving as a building block for hormone synthesis. However, when cholesterol accumulates or is improperly distributed, it can contribute ...
Jul 30, 2025
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37
Hepatic stellate cells (HSCs) are activated to heal the liver when it has a lesion (such as fibrosis or fatty liver); their function is to protect the liver by producing an extracellular matrix comprising collagen, among ...
Jun 10, 2025
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51
An experimental new treatment is showing early promise in the fight against liver fibrosis—a serious and often silent condition that affects around 2 million people in the UK.
May 8, 2025
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16
Chronic liver damage can lead to hepatitis, which causes fibrosis of the liver. This buildup of collagen and other fibrous tissue accelerates when hepatic stellate cells become activated during hepatitis, often resulting ...
Dec 19, 2024
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25
The quest for rejuvenation treatments often targets senescent cells, despite them having a positive physiological role in health in many recent cases, a leading researcher has warned.
Jun 21, 2024
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58
In a world-first, QIMR Berghofer scientists have discovered the mechanism that causes severe inflammation among millions of people with chronic liver disease.
Apr 12, 2024
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81
Currently, the United States lacks FDA-approved treatments for liver fibrosis, highlighting the critical need to understand the cellular biology and pathways associated with this condition.
Nov 1, 2023
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40
Using the latest technologies—including both single-nuclear sequencing of mice and human liver tissue and advanced 3D glass imaging of mice to characterize key scar-producing liver cells—researchers have uncovered novel candidate ...
Jan 4, 2023
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110
Obesity can give rise to a variety of health concerns. Nonalcoholic steatohepatitis (NASH)—a type of fatty liver disease that might progress to cancer—is particularly prevalent among obese people. Treatment for NASH patients ...
Sep 12, 2022
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