MeSH tree: C06.552.150
Primary biliary cholangitis is a rare autoimmune disease that affects the liver and can progress to cirrhosis. It occurs when the immune system attacks the small bile ducts within the liver. As a result, bile builds up, leading ...
Jul 23, 2026
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Metabolic dysfunction-associated steatohepatitis (MASH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are progressive chronic liver diseases linked to abnormal bile acid metabolism. Although ...
Jun 18, 2026
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A team of researchers at Baylor College of Medicine, UMass Chan Medical School and Cincinnati Children's Hospital Medical Center has developed a new treatment that could change the outlook for patients with Alagille syndrome. ...
May 29, 2025
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What influences the extent of scar tissue, or fibrosis, that develops in the liver when people suffer from liver disease? While a small amount of fibrosis is a normal part of the healing process, excessive fibrosis can occur, ...
Oct 4, 2024
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Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine of the University of Pennsylvania (Penn Medicine) developed data designed to improve the diagnosis for Alagille syndrome, a complex ...
Jul 22, 2024
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Using a novel methodology, researchers at The Hospital for Sick Children (SickKids) are the first in pediatric research to use data from an international real-world cohort to overcome the barriers associated with conducting ...
Feb 29, 2024
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Alagille syndrome, a genetic disease estimated to affect 1 in 30,000 individuals, is caused by mutations in the gene JAG1 in most cases. The mutations affect multiple organs including the liver where it often results in cholestasis, ...
Apr 7, 2023
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Research led by Associate Professor Duc Dong, Ph.D., has shown for the first time that the effects of Alagille syndrome, an incurable genetic disorder that affects the liver, could be reversed with a single drug. The study, ...
Jan 5, 2023
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