Validation of a comprehensive genomic profiling assay
A new research paper titled "Analytic validation of NeXT Dx, a comprehensive genomic profiling assay" has been published in Oncotarget.
Aug 30, 2023
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Genetic Phenomena: News and Research on Genomic Instability
MeSH tree: G05.370
New research shows how cancer rewires a key immune pathway to spread
A study led by researchers at Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine discovered a new relationship between cancer cells and the immune system, and shows how cancer can selfishly hijack a normally ...
Aug 23, 2023
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Study offers new understanding of why kidney cancers become metastatic
Researchers at The University of Texas MD Anderson Cancer have engineered a new model of aggressive renal cell carcinoma (RCC), highlighting molecular targets and genomic events that trigger chromosomal instability and drive ...
Jun 26, 2023
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Tethering of shattered chromosomal fragments paves way for new cancer therapies
Healthy cells work hard to maintain the integrity of our DNA, but occasionally, a chromosome can get separated from the others and break apart during cell division. The tiny fragments of DNA then get reassembled in random ...
Jun 15, 2023
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Research finds unexpected link between chromosomal instability and epigenetic alterations
A graduate student's curiosity has uncovered a previously unknown link between two important hallmarks of cancer: chromosomal instability and epigenetic alterations.
Jun 7, 2023
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Study suggests chromosomal errors may hinder some aggressive tumors
Chromosomal errors are a hallmark of cancer cells. Defects in the genome derived from the incorrect separation of chromosomes (and the DNA packed within) in each division of cells drive tumor growth and resistance to therapy.
Apr 24, 2023
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Colorectal cancer patients with African ancestry have fewer clinically actionable alterations than white patients: Study
Genomic profiling of patients who were treated for colorectal cancer at a major U.S. cancer center showed that patients with African ancestry had fewer actionable mutations than patients with European ancestry and were less ...
Apr 17, 2023
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CRISPR therapeutics can damage the genome
Researchers at Tel Aviv University warn that CRISPR therapeutics can damage the genome. They caution: "The CRISPR genome editing method is very effective, but not always safe. Sometimes cleaved chromosomes do not recover ...
Jul 25, 2022
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New insights into melanoma brain metastases
Brain metastasis is one of the most common causes of cancer-related deaths and occurs very frequently in patients with advanced melanoma. Although new immunotherapies are effective in some patients with melanoma brain metastases, ...
Jul 16, 2022
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