Pharmacologic Actions: News and Research on Topoisomerase Inhibitors

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Protein unties tangled DNA linked to hotspots of cancer mutations

New research published in Nature Communications has linked a normal cellular process to an accumulation of DNA mutations in cancer and identified cancer-driving mutations in an underexplored part of the genome.

Dec 4, 2025

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New antibody-drug conjugate shows promising efficacy in EGFR-mutated NSCLC patients

A novel antibody-drug conjugate (ADC), iza-bren (BL-B01D1), demonstrates encouraging safety and efficacy results in previously treated patients with EGFR-mutated non-small cell lung cancer (NSCLC), according to findings presented ...

Sep 6, 2025

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