Urogenital Diseases: News and Research on Glomerulonephritis

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CAR T-cell therapy shows early promise in severe lupus

Early results from a UCL- and UCLH-led clinical trial suggest that a type of CAR T-cell therapy—developed by Autolus Therapeutics, a UCL spinout—could offer a new treatment approach for people with severe, treatment-resistant ...

High levels of gut bacterial toxin trigger lupus nephritis

The body's immune reaction to increased levels of a toxic molecule, part of a bacterial species in the human gut, may reveal who is most at risk of developing lupus nephritis, according to a new study led by NYU Langone Health. ...

New biomarker for immunoglobulin A nephropathy identified

Immunoglobulin A (IgA) nephropathy is an autoimmune disease characterized by the deposition of circulating IgA-containing immune complexes (IgA-ICs) in the glomerular mesangium, leading to mesangial cell proliferation, enhanced ...

Approved IV drug reduces lupus symptoms, clinical trial finds

An already-approved IV drug significantly reduces the symptoms of lupus, a new clinical trial showed. More than three-quarters of lupus patients taking obinutuzumab (Gazvya) had a significant improvement in their symptoms ...

Certain immune cell subtypes drive lupus, study finds

Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell subsets with likely roles in disease pathogenesis, according to a study led by Weill Cornell Medicine ...

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