Broke a tooth? Grow another!

January 13, 2010, Boston University

(PhysOrg.com) -- To all those who have made deals with the tooth fairy in the past: you probably sold your teeth below their fair value.

Dr. George Huang, Chair of Endodontics at the Boston University Henry M. Goldman School of (GSDM), says those baby teeth and extracted third molars we are throwing away hold valuable dental stem cells.

“Our team found for the first team that we can reprogram dental stem cells into human embryonic-like cells called induced pluripotent stem (iPS) cells, which may be an unlimited source of cells for ,” Dr. Huang says.

So far, scientists have had luck creating iPS cells from various cells in mice easily, but this hasn’t been as easy in humans, until more recently. All three types of human dental stem cells the GSDM team tested are easier to reprogram than fibroblasts, which previously seemed to be the best way to make human iPS cells.

In a related study, Dr. Huang regenerated two major human components—dental pulp and dentin—for the first time in a mouse experimental model. The mouse was used to supply nutrition for regeneration.

Using tissue engineering, researchers saw empty root canal space fill with pulp-like tissue with ample blood supplies. Dentin-like tissue regrew on the dentinal wall.

“The finding will revolutionize endodontic and dental clinical practice by helping to preserve teeth,” Dr. Huang says.”

The studies, iPS cells reprogrammed from mesenchymal-like stem/progenitor cells of dental tissue origin and Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model, appear in and Development and Tissue Engineering.

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Simonsez
3 / 5 (2) Jan 13, 2010
This is a pretty amazing discovery!

I am doubly excited by the fact that I have in my possession about a dozen of my own extracted/expelled teeth, including two unbroken wisdom teeth and one extra/third left-front incisor. I wonder if I can sell them now!

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