UGA professor studies link between stress, drug use vulnerability in African Americans

January 13, 2010 by Genevieve di Leonardo

(PhysOrg.com) -- University of Georgia counseling psychology professor Ezemenari M. Obasi believes that the interaction of the environment and one’s genetic makeup can increase drug use vulnerability in rural African Americans.

Obasi has received a two-year $471,683 grant from the National Institute on Drug Abuse, supported by the American Recovery and Reinvestment Act, to conduct research that examines the link between stress and the risk of among rural African Americans.

“African American drug use and abuse behaviors are often characterized by oversimplified models that are rooted in research studies that rarely include them,” said Obasi, a Fellow in UGA’s Institute of Behavioral Research and an assistant professor in the College of Education’s department of counseling and human development services.

There are a wide range of risk factors related to drug addiction, from , personal history and genetic disposition to environmental stressors, said Obasi. He questions whether those risk factors are universal, predictors of all people or group-specific.In this study, he will investigate the possibility that is a risk factor experienced by African Americans.

Such stressors experienced by African Americans residing in a rural community include low socioeconomic status, educational attainment and experiences of discrimination.Counter to popular beliefs, African Americans have a very low drug use rate in comparison to other ethnic groups. Unfortunately, they tend to disproportionately suffer from the negative consequences associated with drug use—including cancers, organ failure, contraction of HIV/AIDS, diminished mental health and treatment in the .

The study will look at two main questions including whether one’s interacts with environmental variables to affect physiological responses to and whether stress dysregulation—the inability of the body to return to a normal state after it experiences stress—predicts drug-related attitudes, craving and history of drug use.

Participants will be recruited from rural counties throughout the state of Georgia.Some of the measured variables will include genotype, hormones, autonomic nervous system responses (heart rate variability and skin conductance), chronic environmental stressors, implicit drug-related cognitions, drug craving and drug use history.

The study will ultimately initiate a multidisciplinary program of research aimed at investigating the impact of the relationship between genetic makeup and environment on drug use vulnerability.According to Obasi, such research is needed in order to inform theory, research, prevention and intervention efforts aimed at the elimination of health disparities that disproportionately impact the African-American community.

The Hwemudua Alcohol and Health Disparities Laboratory, an experimental laboratory developed by Obasi and used to explore the biological, psychological and social pathways concerning the intersection of alcohol use/abuse and health disparities impacting Africans/African Americans residing in the United States, will serve as the setting for this research.

Obasi is working on a research team that was recently awarded a five-year, $5.9 million Core Center of Excellence grant from the National Institute on Drug Abuse to examine the ways genetic tendencies combine with family and community environments to predict drug use and abuse and risky sexual behavior among children, adolescents and young adults. The team is headed by Gene H. Brody, Regents’ Professor Emeritus of Child and Family Development in the UGA College of Family and Consumer Sciences.

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