Protein injection shows promise in lowering elevated triglycerides

Injecting a protein that helps break down triglycerides may someday help treat an inherited form of high triglycerides, according to a new study in Arteriosclerosis, Thrombosis, and Vascular Biology, an American Heart Association journal.

Triglyceride is a type of fat in the blood. Elevated levels in the blood — hypertriglyceridemia — have been linked to coronary artery disease.

In the study, researchers tested a new compound in mice genetically altered to be deficient in a protein called apolipoprotein (apo)A-V, which causes them to have high blood levels of triglycerides. ApoA-V boosts the efficiency of lipoprotein lipase, an enzyme needed to break down triglycerides. The active compound consists of apoA-V complexed with phospholipid to form a reconstituted high density lipoprotein (HDL). The researchers administered the compound in the mice intravenously.

"We asked a simple question: If you just inject apoA-V into these mice that are lacking apoA-V and have very high levels of triglyceride, will it go down?" said Trudy Forte, Ph.D., study senior author and a scientist at Children's Hospital Oakland Research Institute in California. "We were very gratified to see that it went down, and it continued to do so over an eight-hour period."

By the end of the treatment, triglycerides had dropped about 87 percent.

However, in engineered mice lacking a called GPIHBP1, which also leads to very high triglycerides, the apoA-V injection didn't lower levels.

Intravenous apA-V may have a therapeutic benefit in humans with severely elevated due to genetic changes that affect their levels of apoA-V, the researchers said.

Citation: Protein injection shows promise in lowering elevated triglycerides (2010, October 21) retrieved 24 August 2019 from https://medicalxpress.com/news/2010-10-protein-lowering-elevated-triglycerides.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more