Parkinson's drug could treat restless leg syndrome

December 6, 2010

A drug prescribed for Parkinson's disease may also treat restless leg syndrome without the adverse side effects of current therapies, Medical College of Georgia researchers say.

Rasagaline works by prolonging the effect of dopamine, a chemical that transmits signals between in the brain. The cause of RLS is unknown, but research suggests a dopamine imbalance. Parkinson's is caused by a dopamine insufficiency.

"The hope is that Rasagaline, because it prolongs the effect of existing dopamine, instead of producing more, will not come with adverse side effects," said Dr. Shyamal Mehta, an MCG neurologist and neuroscientist. "We are trying to evaluate its safety and efficacy in treating RLS at this point. When it has been used to treat Parkinson's, it's been well-tolerated with few side effects."

Current RLS therapies include a group drugs that work by activating existing , prompting the brain to make more dopamine. The problem, Mehta said, is that those drugs usually come with adverse effects, because dopamine increases feelings of euphoria.

"People taking those drugs often report behavioral problems like addiction, because the pleasure they get from things like shopping is multiplied," he said. "They can cause impulse-control problems, like gambling or as well. They can also cause increased sleepiness and sudden sleep attacks, which can be quite disruptive and dangerous."

Some reports also suggest decreased efficacy after extended use, as well as symptoms beginning earlier in the day.

, which affects 10 percent of the population, is characterized by prickling or tingling in the legs and an urge to move the legs. Symptoms are more noticeable at rest, such as during bedtime or a long car ride. RLS can also cause depression and , Dr. Mehta said, and is linked to conditions including iron deficiency, , pregnancy and Parkinson's.

Related Stories

Recommended for you

In first, scientists forecast West Nile Virus outbreaks

February 24, 2017

Scientists at Columbia University's Mailman School of Public Health are the first to report a method to accurately predict the timing and intensity of West Nile Virus (WNV) outbreaks. The study is published in the journal ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.