Preventing GVHD by protecting gut stem cells

A protein that protects stem cells in the gut relieves a potentially lethal complication of bone marrow transplantation in mice, according to a study published online on January 31 in the Journal of Experimental Medicine.

Bone marrow transplantation can cure diseases such as leukemia but it can also lead to a potentially fatal complication known as graft-versus-host disease (GVHD).

A group led by Takanori Teshima at Kyushu University in Japan found that mice treated with a protein called R-spondin1 developed less severe GVHD after bone marrow transplantation.

R-spondin worked by protecting intestinal , which help to regenerate damaged tissues and thus dampen .

Whether R-spondin1 is therapeutic for human bone marrow transplant patients remains to be explored.


Explore further

Purified blood stem cells improve success of bone marrow transplants in mice, study shows

More information: Takashima, S., et al. 2011. J. Exp. Med. doi:10.1084/jem.20101559
Citation: Preventing GVHD by protecting gut stem cells (2011, January 31) retrieved 13 December 2019 from https://medicalxpress.com/news/2011-01-gvhd-gut-stem-cells.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments