IDSA announces first guidelines for treatment of MRSA infections

January 5, 2011, Infectious Diseases Society of America

Physicians now have help in their battle against methicillin resistant Staphylococcus aureus (MRSA), a potentially deadly infection that initially was limited to hospitals and health care facilities but has become a growing problem in healthy children and adults. The Infectious Diseases Society of America (IDSA) has released its first guidelines for the treatment of increasingly common MRSA infections.

An antibiotic-resistant "superbug," MRSA is responsible for about 60 percent of skin infections seen in emergency rooms. The address treatment of these common infections, which are frequently mistaken for spider bites. They also address treatment of invasive MRSA, which is less common but far more serious, including pneumonia and infections of the blood, heart, bone, joints and . Invasive MRSA kills about 18,000 people every year.

To be published in the Feb. 1 issue of Clinical Infectious Diseases, the guidelines are intended to guide physicians in their use of for treatment of this common infection. Current treatment varies widely.

"MRSA has become a huge public health problem and physicians often struggle with how to treat it," said Catherine Liu, MD, lead author of the guidelines and assistant clinical professor in the Division of Infectious Diseases, University of California, San Francisco. "The guidelines establish a framework to help physicians determine how to evaluate and treat uncomplicated as well as invasive infections. It's designed to be a living document, meaning the recommendations will evolve as new information and antibiotics become available."

MRSA is a type of Staphylococcus aureus ("staph") bacterium that is resistant to first-line antibiotics. Although MRSA can be treated with other types of antibiotics, its resistance to those antibiotics is increasing as well. Overuse and misuse of antibiotics contribute to , and the guidelines note that uncomplicated skin infections often can be treated without the use of antibiotics. The guidelines also call for the development of new and better antibiotics to treat invasive MRSA.

MRSA has been a concern in hospitals for decades (hospital-associated MRSA or HA-MRSA), but in the last 15 years, community strains of MRSA (community-associated MRSA or CA-MRSA) have become a serious problem among healthy people outside of the hospital. CA-MRSA often is spread in locker rooms, dormitories, jails and prisons, in homes and at daycare centers, usually through direct contact or by an object used by an infected person – such as towels, razors and sports equipment. It most frequently causes painful red, swollen bumps about the size of a pencil eraser or golf ball. These bumps often are filled with pus and can appear anywhere on the body, most often at the site of a cut or abrasion or areas covered by hair, such as the back of the neck, groin, buttocks and armpits.

MRSA is a bigger concern when it invades the body beyond the skin. An estimated 94,360 invasive MRSA infections occurred in the United States in 2005, and more than 18,000 people who were infected died, according to a large study published in the Journal of the American Medical Association. Most invasive disease was due to hospital-associated MRSA, but about one in seven cases was due to community-associated MRSA.

Good hygiene is the best defense against MRSA, according to the Centers for Disease Control and Prevention (CDC), including keeping the hands clean, keeping cuts and scrapes clean and covered with a bandage, avoiding contact with other people's wounds, and avoiding sharing personal items such as towels or razors.

The IDSA guidelines address a variety of infections caused by MRSA commonly encountered by emergency room doctors, pediatricians, primary care physicians, hospitalists, infectious diseases specialists, pharmacists and other health care providers. Topics include: how to manage skin and soft tissue infections likely caused by community-associated MRSA; how to treat recurrent skin infections; recommendations regarding use of the intravenous antibiotic vancomycin and other antibiotics used for the treatment of MRSA; how to manage invasive infections, such as pneumonia, and infections in the bones, joints, blood or heart; and how to treat newborns who are infected with MRSA.

The guidelines were reviewed and endorsed by the Pediatric Infectious Diseases Society, the American College of Emergency Physicians, and the American Academy of Pediatrics. The voluntary guidelines are not intended to take the place of a doctor's judgment, but rather support the decision-making process, which must be individualized according to each patient's circumstances.

The 13-member guidelines panel comprised of MRSA experts from around the country reviewed hundreds of scientific studies, papers and presentations. In addition to Dr. Liu, the MRSA guidelines panel includes: Arnold Bayer, Sara E. Cosgrove, Robert S. Daum, Scott K. Fridkin, Rachel J. Gorwitz, Sheldon L. Kaplan, Adolf W. Karchmer, Donald P. Levine, Barbara E. Murray, Michael J. Rybak, David A. Talan, and Henry F. Chambers.

Related Stories

Recommended for you

Past encounters with the flu shape vaccine response

February 20, 2018
New research on why the influenza vaccine was only modestly effective in recent years shows that immune history with the flu influences a person's response to the vaccine.

Building better tiny kidneys to test drugs and help people avoid dialysis

February 16, 2018
A free online kidney atlas built by USC researchers empowers stem cell scientists everywhere to generate more human-like tiny kidneys for testing new drugs and creating renal replacement therapies.

Expanding Hepatitis C testing to all adults is cost-effective and improves outcomes

February 16, 2018
According to a new study, screening all adults for hepatitis C (HCV) is a cost-effective way to improve clinical outcomes of HCV and identify more infected people compared to current recommendations. Using a simulation model, ...

Study suggests expanded range for emerging tick-borne disease

February 16, 2018
Human cases of Borrelia miyamotoi, a tick-borne infection with some similarities to Lyme disease, were discovered in the eastern United States less than a decade ago. Now new research led by the Yale School of Public Health ...

Flu shot only 36 percent effective, making bad year worse (Update)

February 15, 2018
The flu vaccine is doing a poor job protecting older Americans and others against the bug that's causing most illnesses.

IFN-mediated immunity to influenza A virus infection influenced by RIPK3 protein

February 15, 2018
Each year, influenza kills half a million people globally with the elderly and very young most often the victims. In fact, the Centers for Disease Control and Prevention reported 37 children have died in the United States ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.