Diet and exercise restore immune function in obesity
(PhysOrg.com) -- Boston University scientists say that moderate daily exercise and dietary control might reverse immune dysfunctions found in people with obesity.
Research has suggested that a change in immune function is a predecessor to all these diseases and researchers at Boston University Henry M. Goldman School of Dental Medicine (GSDM) have previously shown that obesity causes immune defects that make it hard to fight infection.
Until now, little was known about how diet and exercise affects immunity in obese people.
Researchers worked with diet-induced obese mice in four groups:
lean mice on a standard chow diet
obese mice on a high fat diet
obese mice on a high fat diet on a moderate exercise plan for four weeks, and
obese, high fat diet mice given moderate exercise and a four-week standard chow diet
Moderate daily exercise and dietary control dramatically restored immune function. Obese mice saw damaged cytokinessignaling molecules that help immune cells talk to each otherrepaired and an improved ability to fight gum disease as measured by bone loss.
The study underscores the necessity to correct two important factors in obesitydiet and exerciseto improve markers of immune dysfunction and bone loss, says senior author Dr. Salomon Amar. The correction of one factor only may not lead to any tangible changes.