Breast cancer patients needed for trial to assess imaging technique for mastectomies

October 25, 2011 BY TANYA LEWIS

Researchers at the Stanford University School of Medicine are recruiting women with breast cancer to test whether a technique to image tissue blood flow could help reduce complications after mastectomy surgery.

Breast cancer strikes about one in eight women in the United States, according to from the U.S. National Library of Medicine. Surgical treatment can involve removing the () or the entire breast (), which may be followed by with .

Advances in reconstructive techniques and skin-sparing mastectomies have made more cosmetically pleasing mastectomies possible. Yet these operations pose a greater . “Post-operative complications can arise from skin loss, infections and implant rejection,” said Irene Wapnir, MD, associate professor of surgery and chief of Stanford’s breast surgery program. These can be related to problems of adequate blood supply, or perfusion, to the skin.

Wapnir and Geoffrey Gurtner, MD, professor and associate chair of surgery, are leading a study to see if SPY Elite imaging can improve on the standard technique of the surgeon’s clinical judgment, which relies on visual inspection of skin color and bleeding. Such clinical judgments are “very hard for the surgeon to make,” said Wapnir, who will use the perfusion imaging to aid in making surgical incisions. The imaging system is already being used in procedures ranging from bypass surgery to organ transplant.

This imaging procedure involves injecting a fluorescent green dye into the blood stream and using a special infrared camera to visualize blood vessels. It allows surgeons to keep track of the blood supply to the breast skin after mastectomy and during reconstructive surgery. LifeCell Corp., distributer of the imaging system, provided the funding for the study. Neither Wapnir nor Gurtner has financial ties or consulting relationships with the company.

The researchers are recruiting 100 female patients age 18 and older who are undergoing mastectomy with immediate or delayed breast reconstruction. Women seeking skin-sparing and nipple-sparing mastectomies are ideal candidates for this study. Women who are pregnant, allergic to iodine, or have liver or kidney failure are not eligible.

Participants will be randomly assigned to one of two groups, both of which will receive the surgical imaging. For group one, both Wapnir and Gurtner will view the perfusion images and make clinical observations of perfusion. For group two, only Wapnir will view the perfusion images, whereas Gurtner will make clinical observations without viewing them. Wapnir emphasized the importance of having two groups to assess whether the imaging adds value and aids decision-making during the procedure.

Participants will have standard pre-operative and post-operative appointments. The study will also evaluate long-term breast skin features, such as color and temperature, over the first year following the surgery. The trial itself will span two years.

Using the imaging, researchers hope to see whether assuring adequate blood supply to the breast skin reduces the rate of complications during mastectomy and reconstruction. Furthermore, Wapnir said they aim to ultimately improve cosmetic outcomes.

Explore further: Most breast cancer patients do not have breast reconstruction surgery

Related Stories

Most breast cancer patients do not have breast reconstruction surgery

October 20, 2011
Only seven per cent of female breast cancer patients opt for breast reconstruction surgery.

Breast cancer surgery preserves artery for future heart surgery

October 18, 2011
(Medical Xpress) -- Doctors at Johns Hopkins have shown that during an increasingly popular type of breast-reconstruction surgery, they can safely preserve the internal mammary artery, in case it is needed for future cardiac ...

Recommended for you

Researchers release first draft of a genome-wide cancer 'dependency map'

July 27, 2017
In one of the largest efforts to build a comprehensive catalog of genetic vulnerabilities in cancer, researchers from the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute have identified more than 760 genes ...

Cancer-death button gets jammed by gut bacterium

July 27, 2017
Researchers at Michigan Medicine and in China showed that a type of bacterium is associated with the recurrence of colorectal cancer and poor outcomes. They found that Fusobacterium nucleatum in the gut can stop chemotherapy ...

Long-sought mechanism of metastasis is discovered in pancreatic cancer

July 27, 2017
Cells, just like people, have memories. They retain molecular markers that at the beginning of their existence helped guide their development. Cells that become cancerous may be making use of these early memories to power ...

Blocking the back-door that cancer cells use to escape death by radiotherapy

July 27, 2017
A natural healing mechanism of the body may be reducing the efficiency of radiotherapy in breast cancer patients, according to a new study.

Manmade peptides reduce breast cancer's spread

July 27, 2017
Manmade peptides that directly disrupt the inner workings of a gene known to support cancer's spread significantly reduce metastasis in a mouse model of breast cancer, scientists say.

Glowing tumor technology helps surgeons remove hidden cancer cells

July 27, 2017
Surgeons were able to identify and remove a greater number of cancerous nodules from lung cancer patients when combining intraoperative molecular imaging (IMI) - through the use of a contrast agent that makes tumor cells ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.