Retinal microvascular changes associated with disability in daily activities among older adults

November 14, 2011

Retinal microvascular changes appear to be associated with development of disability in performing activities of daily living among older adults, and retinal signs may be useful in predicting outcomes among this population, according to a report published Online First by Archives of Ophthalmology.

"We have recently found that a higher burden of retinal signs was associated with poor executive function and physical function in a cross-sectional analysis," the authors write as background information in the article. "Based on this evidence, we hypothesized that retinal signs might predict future disability in performing activities of ."

Using data collected during the Cardiovascular Health Study, a population-based study of community-dwelling older adults, Dae Hyun Kim, M.D., M.P.H., of the Beth Israel Deaconess Medical Center and Harvard School of Public Health, Boston, and colleagues examined the association of retinal microvascular changes with disability to perform activities of daily living. Retinal signs that were measured included generalized arteriolar narrowing, generalized venular widening, retinopathy, arteriovenous nicking, and focal arteriolar narrowing.

At the baseline examination, the overall prevalence of retinal signs was 7.1 percent (92 of 1,294) for retinopathy, 7.5 percent (85 of 1,135) for arteriovenous nicking (constriction of a vein in the at an where it crosses an artery) and 10.4 percent (111 or 1,063) for focal arteriolar narrowing. Patients with two or more retinal signs comprised 6.9 percent (61 of 880) of the study population with complete retinal data. During a median follow-up of 3.1 years (maximum, 7.8 years) and after adjusting for other factors, the presence of two or more retinal signs was associated with a 1.45-fold increased rate of disability; however, individual retinal signs were not.

Further analysis showed that the presence of two or more retinal signs was associated with disability compared with having no signs, while having one retinal sign was not. The authors found no particular combinations of retinal signs that showed greater risk than others. Additionally, the association was independent of vascular risk factors and carotid atherosclerosis, and among those without diabetes or clinical cardiovascular disease.

"Our study supports the hypothesis that microvascular disease accelerates age-related disability and retinal signs can be useful in understanding mechanisms and predicting outcomes," the authors conclude. They also note that, "our study suggests that the presence of two or more retinal signs may be an early marker of microvascular disease that portends an elevated risk for future activities of daily living disability in community-dwelling independently of major risk factors for disability and microvascular disease on brain MRI."

Explore further: Kids' 'screen time' linked to early markers for cardiovascular disease

More information: Arch Ophthalmol. Published online November 14, 2011. doi:10.1001/archophthalmol.2011.360

Related Stories

Kids' 'screen time' linked to early markers for cardiovascular disease

April 20, 2011
Six-year-olds who spent the most time watching television, using a computer or playing video games had narrower arteries in the back of their eyes — a marker of future cardiovascular risk, in a first-of-its-kind study ...

Recommended for you

To combat teen smoking, health experts recommend R ratings for movies that depict tobacco use

July 21, 2017
Public health experts have an unusual suggestion for reducing teen smoking: Give just about any movie that depicts tobacco use an automatic R rating.

Aging Americans enjoy longer life, better health when avoiding three risky behaviors

July 20, 2017
We've heard it before from our doctors and other health experts: Keep your weight down, don't smoke and cut back on the alcohol if you want to live longer.

Opioids and obesity, not 'despair deaths,' raising mortality rates for white Americans

July 20, 2017
Drug-related deaths among middle-aged white men increased more than 25-fold between 1980 and 2014, with the bulk of that spike occurring since the mid-1990s when addictive prescription opioids became broadly available, according ...

Parents have critical role in preventing teen drinking

July 20, 2017
Fewer teenagers are drinking alcohol but more needs to be done to curb the drinking habits of Australian school students, based on the findings of the latest study by Adelaide researchers.

Fresh fish oil lowers diabetes risk in rat offspring

July 19, 2017
Fresh fish oil given to overweight pregnant rats prevented their offspring from developing a major diabetes risk factor, Auckland researchers have found.

High-dose vitamin D doesn't appear to reduce the winter sniffles for children

July 18, 2017
Giving children high doses of vitamin D doesn't appear to reduce the winter sniffles, a new study has found.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.