Cells use allergic response to protect against cancer-causing damage
(Medical Xpress) -- CANCER RESEARCH UK scientists have found that the bodys surveillance for cancer causing damage and its response to allergies share a common pathway, according to research published in Science.
Looking at the effect this can have on mouse skin cells, the researchers at Kings College London and Cancer Research UKs London Research Institute found damaged cells display a stress molecule that activates neighbouring immune cells to destroy them.
But, unexpectedly, the scientists also found that this activates another response that involves the bodys whole immune system, similar to the allergic response the body uses to mop up allergens such as pollen.
The stress molecules also trigger a separate part of the bodys defence system to produce large amounts of antibodies typically linked to an allergic response. The researchers think they are used by the body to recognise and flag the toxins that have caused the damage, clearing them before they affect the rest of the body.
This combination allows the immune system to see and respond to developing tumours on the bodys surface and initiate allergic-type reactions to protect the rest of the body.
Professor Adrian Hayday, based both at Cancer Research UKs London Research Institute and Kings College London, said: There has been a great amount of interest in immunotherapy using the bodys own defences to treat cancer - recently, but our understanding of how the immune response works to recognise and halt cancer growth has been limited. Our study suggests new and simple ways for monitoring a patients anti-tumour responses during treatment allowing us to see if chemotherapy, for example, is helping or hindering the bodys own response to tumours.
Study author Dr Jessica Strid, at Kings College London, said: The body uses many different pathways to deal with threats and damage and we only understand how they work individually. Our study offers a fresh perspective on how the body regulates its response to carcinogens, using the allergic response to remove them before they spread to the rest of the body.
Dr Julie Sharp, senior science information manager at Cancer Research UK, said: Our bodys surfaces are constantly exposed to potentially cancer causing damage. This research shows how the body can quickly react to eradicate potentially cancerous cells and clear damaging toxins from the rest of the body. Understanding how this works could pave the way to more effective treatments that use the bodys immune system to track down and destroy cancer cells.