Prediabetes may not explain diabetic polyneuropathies

February 22, 2012

In a reversal of two decades of medical reports, a Mayo Clinic study finds the frequency of nerve damage called diabetic polyneuropathy is similar in prediabetic patients and healthy people. Physicians should seek explanations other than prediabetes for patients who have painful small fiber polyneuropathy, the researchers say. The study was published in the February issue of Diabetes Care.

Diabetic polyneuropathies, or DPN, are commonly associated with diabetes and chemical derangements related to . The neuropathies can injure throughout the body, but usually affect the feet and legs. The can create sensory, motor and bodily function problems. DPN can be painful and life-threatening.

"It is highly unlikely that impaired glucose or associated metabolic derangements cause polyneuropathy, at least not to the high frequency previously reported," says lead author Peter J. Dyck, M.D., a Mayo Clinic neurologist.

The five-year study, "Impaired Glycemia and Diabetic Polyneuropathy: The OC IG Survey," tested nearly 550 people representative of a community of older patients of Northern European extraction. Of these, 150 individuals were healthy subjects, 174 had prediabetes indicators, and 208 had newly developed type 2 diabetes. The study concluded that typical or atypical (a painful small-fiber variety) DPN was not more prevalent in prediabetics than in healthy people.

While the researchers agree that prediabetes is a precursor of type 2 diabetes, they found no evidence that it directly leads to greater prevalence of typical or atypical DPN. Attempts should be made to prevent the development of type 2 diabetes; however, considering the complications from overtreatment, the study suggests physicians should avoid treatment of as diabetes if their intention is to prevent the development of diabetic polyneuropathy, the researchers say.

Related Stories

Recommended for you

Diabetes can be tracked with our Google searches

July 26, 2017
The emergence of Type 2 Diabetes could be more effectively monitored using our Google searches—helping public health officials keep track of the disease and halt its spread—according to research by the University of Warwick.

Scientists discover a new way to treat type 2 diabetes

July 21, 2017
Medication currently being used to treat obesity is also proving to have significant health benefits for patients with type 2 diabetes. A new study published today in Molecular Metabolism explains how this therapeutic benefit ...

Alzheimer's drug cuts hallmark inflammation related to metabolic syndrome by 25 percent

July 20, 2017
An existing Alzheimer's medication slashes inflammation and insulin resistance in patients with metabolic syndrome, a potential therapeutic intervention for a highly dangerous condition affecting 30 percent of adults in the ...

Diabetes or its precursor affects 100 million Americans

July 19, 2017
Almost one-third of the US population—100 million people—either has diabetes or its precursor condition, known as pre-diabetes, said a government report Tuesday.

One virus may protect against type 1 diabetes, others may increase risk

July 11, 2017
Doctors can't predict who will develop type 1 diabetes, a chronic autoimmune disease in which the immune system destroys the cells needed to control blood-sugar levels, requiring daily insulin injections and continual monitoring.

Diabetes complications are a risk factor for repeat hospitalizations, study shows

July 7, 2017
For patients with diabetes, one reason for hospitalization and unplanned hospital readmission is severe dysglycemia (uncontrolled hyperglycemia - high blood sugar, or hypoglycemia - low blood sugar), says new research published ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.