Fewer mitochondria in offspring of parents with diabetes

March 26, 2012
Fewer mitochondria in offspring of parents with diabetes
Normal-weight, insulin-resistant individuals whose parents have type 2 diabetes have fewer mitochondria in their muscles due to lower expression of lipoprotein lipase, according to a study published in the April issue of Diabetes.

(HealthDay) -- Normal-weight, insulin-resistant individuals whose parents have type 2 diabetes have fewer mitochondria in their muscles due to lower expression of lipoprotein lipase (LPL), according to a study published in the April issue of Diabetes.

Katsutaro Morino, from the Yale University School of Medicine in New Haven, Conn., and colleagues examined gene expression and their potential involvement in regulating mitochondrial biogenesis in skeletal muscle from 11 young, lean, insulin-resistant offspring of parents with type 2 diabetes and 11 insulin-sensitive subjects without a family history of type 2 diabetes.

The researchers found that the insulin-resistant subjects had significantly lower and of LPL in skeletal muscle, which was associated with reduced mitochondrial density. deficient in LPL had lower mitochondrial content due to reduced fatty acid delivery and reduced activation of the peroxisome proliferator-activated receptor-δ (PPAR-δ).

"Taken together, these data suggest that decreased mitochondrial content in muscle of insulin-resistant offspring may be due in part to reductions in LPL expression in skeletal muscle resulting in decreased PPAR-δ activation," Morino and colleagues conclude.

Explore further: Saturated fatty acids lead to mitochondrial dysfunction and insulin resistance

More information: Abstract
Full Text (subscription or payment may be required)


Related Stories

Saturated fatty acids lead to mitochondrial dysfunction and insulin resistance

January 20, 2012
Excessive levels of certain saturated fatty acids cause mitochondria to fragment, leading to insulin resistance in skeletal muscle, a precursor of type 2 diabetes, according to a paper in the January issue of the journal ...

Researchers identify new target for treatment of type 2 diabetes and prediabetes

August 22, 2011
Researchers at the Joslin Diabetes Center have shown that an enzyme found in the mitochondria of cells is decreased in the skeletal muscle of those with diabetes, a finding that could lead to the development of drugs to boost ...

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Thirty-year study shows women who breastfeed for six months or more reduce their diabetes risk

January 16, 2018
In a long-term national study, breastfeeding for six months or longer cuts the risk of developing type 2 diabetes nearly in half for women throughout their childbearing years, according to new Kaiser Permanente research published ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.