Retinol supplementation may lower melanoma risk

March 5, 2012
Retinol supplementation may lower melanoma risk
Retinol supplementation is associated with a lower risk of melanoma, according to research published online March 1 in the Journal of Investigative Dermatology.

(HealthDay) -- Retinol supplementation is associated with a lower risk of melanoma, according to research published online March 1 in the Journal of Investigative Dermatology.

Maryam M. Asgari, M.D., M.P.H., of Kaiser Permanente Northern California in Oakland, and colleagues evaluated data from 69,635 adults who participated in the VITamins And Lifestyle (VITAL) to determine whether there was an association between dietary and supplemental vitamin A and carotenoid intake and risk.

In the 5.84 years of follow-up, the researchers identified 566 incident melanomas. Baseline use of retinol supplements correlated with a significant decrease in the risk of melanoma (hazard ratio [HR], 0.60). Compared with nonusers, adults who took high-dose retinol supplements (>1,200 µg per day) had a significantly lower risk of melanoma (HR, 0.74), particularly in areas of the body exposed to the sun. Dietary or total intake of vitamin A or carotenoids, however, was not associated with a reduced risk of melanoma.

"Our data, which are based on a large prospective cohort, suggest that retinol intake from individual is associated with a reduction in risk for melanoma, especially among women. Our findings suggest that vitamin A supplementation may hold promise as a chemopreventive agent for melanoma," the authors write.

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Roland
not rated yet Mar 06, 2012
This article needs work on the units. Per Wikipedia: "1 IU of retinol is equivalent to approximately 0.3 micrograms", so the article apparently recommends 4,000 IU, 10x the US "Recommended Daily Allowance". The "Tolerable Upper Intake Level" is 3,000 micrograms/day, or about 10,000 IU. This is a "Therapeutic Ratio" of only 2.5:1, which would make Retinol a very dangerous drug indeed! 25:1 for the RDA is much safer. I hope my math is correct.

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