Gene expression profile testing increasing in breast cancer

May 18, 2012
Gene expression profile testing increasing in breast cancer

(HealthDay) -- From 2006 to 2008, the use of gene expression profile (GEP) testing increased, correlating with a decrease in the percentage of women with hormone receptor (HR)-positive breast cancer receiving adjuvant chemotherapy, according to a study published online May 14 in the Journal of Clinical Oncology.

Michael J. Hassett, M.D., M.P.H., of the Dana-Farber Cancer Institute in Boston, and colleagues conducted a prospective study that assessed GEP testing and its association with subsequent chemotherapy use in 7,375 women diagnosed with HR-positive from 2006 to 2008 at 17 cancer centers.

The researchers found that, of the total participants, 20.4 percent received GEP testing and 50.2 received chemotherapy. From 2006 to 2008, GEP testing increased significantly, from 14.7 to 27.5 percent, and chemotherapy use decreased significantly, from 53.9 to 47.0 percent. The likelihood of testing was lower for African-American versus white women (odds ratio [OR], 0.70) and for those with high school or less versus more than high school education (OR, 0.63). Testing correlated with significantly decreased odds of chemotherapy use overall (OR, 0.70). In stratified analyses, testing correlated with increased odds of chemotherapy use in small, node-negative cancers (OR, 11.13), and with lower odds of chemotherapy use for node-positive and large, node-negative cancers (OR, 0.11).

"Our findings suggest that GEP testing may be associated with a change in the type of patients who receive chemotherapy and with the omission of chemotherapy for those unlikely to benefit," the authors write.

Explore further: Chemotherapy's effect on overall survival seems to increase based on tumor size

More information: Abstract
Full Text (subscription or payment may be required)
Editorial

Related Stories

Chemotherapy's effect on overall survival seems to increase based on tumor size

May 15, 2012
The most recent research released in June's Journal of Thoracic Oncology indicates there might be a positive correlation between tumor size and adjuvant platinum based chemotherapy in surgically resected patients with node ...

Adjuvant therapy shows promise in biliary tract cancer

April 27, 2012
(HealthDay) -- For patients with biliary tract cancers, postresection adjuvant therapy with chemotherapy or chemoradiotherapy appears to be beneficial in treating patients with biliary tract cancers, with significant improvement ...

Breast cancer treatment shows benefit for women with small, localized disease

June 28, 2011
Memorial Sloan-Kettering Cancer Center physician-scientists report that women with small, node-negative, HER2-positive breast cancer may obtain a significant benefit from adjuvant chemotherapy with trastuzumab (Herceptin), ...

Trastuzumab and chemotherapy improved survival in HER2-postive breast and brain cancer patients

July 18, 2011
The use of trastuzumab, chemotherapy and surgery among women with HER2-positive metastatic breast cancer significantly improved survival from the time central nervous system metastases were diagnosed.

Hormone test predicts ovarian function after chemotherapy for breast cancer

June 6, 2011
A test that shows how many eggs a woman has in her ovaries may help young women with breast cancer know what their reproductive function will be after chemotherapy, a new study finds. The results will be presented Sunday ...

Recommended for you

T-cells engineered to outsmart tumors induce clinical responses in relapsed Hodgkin lymphoma

January 16, 2018
WASHINGTON-(Jan. 16, 2018)-Tumors have come up with ingenious strategies that enable them to evade detection and destruction by the immune system. So, a research team that includes Children's National Health System clinician-researchers ...

Researchers identify new treatment target for melanoma

January 16, 2018
Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous ...

More evidence of link between severe gum disease and cancer risk

January 16, 2018
Data collected during a long-term health study provides additional evidence for a link between increased risk of cancer in individuals with advanced gum disease, according to a new collaborative study led by epidemiologists ...

Researchers develop a remote-controlled cancer immunotherapy system

January 15, 2018
A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells.

Dietary fat, changes in fat metabolism may promote prostate cancer metastasis

January 15, 2018
Prostate tumors tend to be what scientists call "indolent" - so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, ...

Pancreatic tumors may require a one-two-three punch

January 15, 2018
One of the many difficult things about pancreatic cancer is that tumors are resistant to most treatments because of their unique density and cell composition. However, in a new Wilmot Cancer Institute study, scientists discovered ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.