Obese asthma patients have reduced treatment response

June 25, 2012
Obese asthma patients have reduced treatment response
Compared with lean patients, obese patients with asthma have higher neutrophil counts and a reduced response to corticosteroid treatment, according to a study published online June 12 in Allergy.

(HealthDay) -- Compared with lean patients, obese patients with asthma have higher neutrophil counts and a reduced response to corticosteroid treatment, according to a study published online June 12 in Allergy.

Eef D. Telenga, M.D., of the University of Groningen in the Netherlands, and colleagues conducted a study involving 63 obese and 213 lean asthma patients from four cohorts to determine whether severe and airway hyper-responsiveness differs between the groups. They also examined the influence of obesity on the response to corticosteroid treatment in 118 patients.

The researchers found that, at baseline, asthma severity was comparable between the groups. Significantly higher blood neutrophil counts were seen in obese patients, specifically in obese women, but not obese men. Compared with lean patients, obese patients demonstrated significantly less corticosteroid-induced improvement in forced expiratory volume in 1 second after a two-week treatment period with corticosteroids (median 1.7 versus 6.3 percent). There was a significantly lower improvement in the percentage of sputum with increased and a smaller improvement in blood neutrophil counts in obese versus lean patients.

"The results of our study show that obese asthma patients have a distinct phenotype of asthma that is characterized by a higher level of neutrophilic inflammation in sputum and blood. Especially, obese female asthma [patients] show this increased neutrophilic inflammation," the authors write. "The increased neutrophilic inflammation may help to explain why obese respond less to corticosteroid treatment."

Several authors disclosed to pharmaceutical companies, including GlaxoSmithKline, which funded two of the cohorts in this study.

Abstract

Full Text (subscription or payment may be required)

Explore further: Risk misdiagnosis for obese patients

Related Stories

Risk misdiagnosis for obese patients

August 18, 2011
The prevalence of physician-diagnosed asthma is increasing partly because of a link between asthma and obesity.

Inflammation a possible cause of higher mortality rates in older asthma patients

May 21, 2012
Higher mortality rates among older adult asthma patients compared to their younger counterparts may be due, at least in part, to an increase in airway inflammation, according to a study conducted by researchers in Canada, ...

Heavy kids may not respond as well to asthma meds

March 4, 2012
(HealthDay) -- Overweight children may not respond as well to common asthma medicines known as inhaled corticosteroids, new research finds.

Recommended for you

Nearly 4 in 10 U.S. adults now obese (Update)

October 13, 2017
(HealthDay)—Almost forty percent adults in the United States are now obese, continuing an ever-expanding epidemic of obesity that's expected to lead to sicker Americans and higher health care costs.

Tenfold increase in childhood and adolescent obesity in four decades, new study finds

October 10, 2017
The number of obese children and adolescents (aged 5 to 19 years) worldwide has risen tenfold in the past four decades, according to a new study led by Imperial College London and the World Health Organization (WHO). If current ...

Working night shifts may widen your waistline

October 4, 2017
(HealthDay)—Workers who regularly pull overnight shifts may be more prone to pack on the pounds, a new analysis suggests.

Weight loss for adults at any age leads to cost savings, study suggests

September 26, 2017
Helping an adult lose weight leads to significant cost savings at any age, with those savings peaking at age 50, suggests a new Johns Hopkins Bloomberg School of Public Health study.

U.S. pays a hefty price for obesity

September 26, 2017
(HealthDay)—A U.S. adult who is "healthy" but obese could eventually cost society tens of thousands of dollars in medical care and lost wages, a new study estimates.

Living near fast food outlets linked to weight gain in primary school children

September 11, 2017
Children with greater access to fast food outlets are more likely to gain weight compared to those living further away, new research suggests.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.