Cetuximab, paclitaxel combo active in urothelial cancer

August 29, 2012
Cetuximab, paclitaxel combo active in urothelial cancer
The monoclonal antibody against epidermal growth factor receptor, cetuximab, augments the antitumor activity of paclitaxel in patients with previously treated urothelial cancer, according to a study published online Aug. 27 in the Journal of Clinical Oncology.

(HealthDay)—The monoclonal antibody against epidermal growth factor receptor (EGFR), cetuximab, augments the antitumor activity of paclitaxel in patients with previously treated urothelial cancer, according to a study published online Aug. 27 in the Journal of Clinical Oncology.

Yu-Ning Wong, M.D., of the Fox Chase Cancer Center in Philadelphia, and colleagues conducted a phase II, randomized, noncomparative study involving 39 patients with metastatic urothelial cancer to determine the benefits of salvage chemotherapy with cetuximab with or without paclitaxel.

In the single-agent cetuximab treatment arm, the researchers found that nine of 11 patients had progressed by eight weeks, and the arm was closed. For the 28 patients enrolled in the cetuximab plus paclitaxel arm, 12 experienced progression-free survival (PFS) longer than 16 weeks. The overall response rate was 25 percent, including three complete responses and four partial responses. The median PFS and overall survival were 16.4 and 42 weeks, respectively. Grade 3 and 4 treatment-related adverse events included rash in six patients, fatigue in five patients, and low magnesium in three cases.

"In conclusion, although cetuximab is inactive as a single agent in advanced urothelial cancer, it may augment the antitumor activity of paclitaxel when given in combination," the authors write. "The combination of paclitaxel and cetuximab should be compared with single-agent paclitaxel in a to establish the role of EGFR inhibition by in advanced urothelial cancers."

Several authors disclosed to Bristol-Myers Squibb, which funded the study and manufactures .

Explore further: High EGFR expression a predictor for improved survival with cetuximab plus chemotherapy

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

High EGFR expression a predictor for improved survival with cetuximab plus chemotherapy

July 5, 2011
High epidermal growth factor receptor (EGFR) expression was a good predictor of which lung cancer patients would survive longer when cetuximab (Erbitux) was added to first-line chemotherapy, according to research presented ...

Study combines lapatinib with cetuximab to overcome resistance in EGFR-driven tumors

May 16, 2012
Targeted therapies have been studied for years, but recent laboratory research is providing robust clues about drugs that might work better in combination, particularly in treating cancers that have become resistant to therapy. ...

Recommended for you

Lung cancer triggers pulmonary hypertension

November 17, 2017
Shortness of breath and respiratory distress often increase the suffering of advanced-stage lung cancer patients. These symptoms can be triggered by pulmonary hypertension, as scientists at the Max Planck Institute for Heart ...

Researchers discover an Achilles heel in a lethal leukemia

November 16, 2017
Researchers have discovered how a linkage between two proteins in acute myeloid leukemia enables cancer cells to resist chemotherapy and showed that disrupting the linkage could render the cells vulnerable to treatment. St. ...

Computer program finds new uses for old drugs

November 16, 2017
Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs. The computer program, called DrugPredict, ...

Pharmacoscopy improves therapy for relapsed blood cancer in a first clinical trial

November 16, 2017
Researchers at CeMM and the Medical University of Vienna presented a preliminary report in The Lancet Hematology on the clinical impact of an integrated ex vivo approach called pharmacoscopy. The procedures measure single-cell ...

Wider sampling of tumor tissues may guide drug choice, improve outcomes

November 15, 2017
A new study focused on describing genetic variations within a primary tumor, differences between the primary and a metastatic branch of that tumor, and additional diversity found in tumor DNA in the blood stream could help ...

A new strategy for prevention of liver cancer development

November 14, 2017
Primary liver cancer is now the second leading cause of cancer-related death worldwide, and its incidences and mortality are increasing rapidly in the United Stated. In late stages of the malignancy, there are no effective ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.