Genetic clues for type 2 diabetes

August 14, 2012, University of Western Australia
The two studies identified 53 loci (regions on the chromosome where genes are located) that are linked to glycemic traits and type 2 diabetes. The research could help scientists develop a tool to detect the risk of developing type 2 diabetes. Image: fpm/iStockphoto

Busselton residents and researchers from The University of Western Australia have contributed to a worldwide scientific collaboration that has identified new genetic links in the quest to map the biological pathways that cause diabetes.

In two papers published online today in , the researchers have identified a substantial number of new loci (the specific place on a chromosome where a gene is located) linked with glycemic traits and (T2D) that have not been described in previous research.

Diabetes is a condition where there is too much glucose, a type of sugar, in the blood.  Type 2 diabetes is the most common form of diabetes affecting some 90 per cent of all people with diabetes. It is sometimes described as a ‘lifestyle disease' strongly associated with high blood pressure, high cholesterol and obesity.

In the study ‘Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes' researchers extended the discovery and characterisation of variants influencing susceptibility to T2D.

The study expanded T2D association analysis to almost 150,000 individuals and in so doing added another 10 loci to the list of confirmed variant signals. It also concluded that genetic profiling had the potential to provide a useful risk assessment for developing T2D.

The second paper titled "Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways" discovered another 38 new loci with glycemic traits not described in previous research, taking the total number of signals influencing glycemic traits to 53.

"This research will provide a better understanding of the genes associated with glycemic control that may interact with environmental factors and trigger diabetes," co-author Dr Jennie Hui from the UWA Schools of Pathology and Laboratory Medicine and Population Health said.

Explore further: Genetic risks for type 2 diabetes span multiple ethnicities

Related Stories

Genetic risks for type 2 diabetes span multiple ethnicities

February 9, 2012
A recent large and comprehensive analysis of 50,000 genetic variants across 2,000 genes linked to cardiovascular and metabolic function has identified four genes associated with type 2 diabetes (T2D) and six independent disease-associated ...

Metabolic MAGIC: Meta-analyses reveal new genetic regions influencing blood glucose traits

August 12, 2012
Researchers have identified 38 new genetic regions that are associated with glucose and insulin levels in the blood. This brings the total number of genetic regions associated with glucose and insulin levels to 53, over half ...

Glycemic variability affects mood and quality of life

May 10, 2012
(HealthDay) -- Glycemic variability appears to be associated with lower quality of life and negative moods in women with type 2 diabetes, according to a study published in the March 30 issue of Diabetes Technology & Therapeutics.

Gene profile correlates with glycemia in type 1 diabetes

March 16, 2012
(HealthDay) -- A gene expression profile in peripheral blood correlates with glycemic control in the first year for patients recently diagnosed with type 1 diabetes, according to a study published online March 8 in Diabetes.

Recommended for you

Epigenetics study helps focus search for autism risk factors

January 16, 2018
Scientists have long tried to pin down the causes of autism spectrum disorder. Recent studies have expanded the search for genetic links from identifying genes toward epigenetics, the study of factors that control gene expression ...

Study advances gene therapy for glaucoma

January 16, 2018
While testing genes to treat glaucoma by reducing pressure inside the eye, University of Wisconsin-Madison scientists stumbled onto a problem: They had trouble getting efficient gene delivery to the cells that act like drains ...

Group recreates DNA of man who died in 1827 despite having no body to work with

January 16, 2018
An international team of researchers led by a group with deCODE Genetics, a biopharmaceutical company in Iceland, has partly recreated the DNA of a man who died in 1827, despite having no body to take tissue samples from. ...

The surprising role of gene architecture in cell fate decisions

January 16, 2018
Scientists read the code of life—the genome—as a sequence of letters, but now researchers have also started exploring its three-dimensional organisation. In a paper published in Nature Genetics, an interdisciplinary research ...

How incurable mitochondrial diseases strike previously unaffected families

January 15, 2018
Researchers have shown for the first time how children can inherit a severe - potentially fatal - mitochondrial disease from a healthy mother. The study, led by researchers from the MRC Mitochondrial Biology Unit at the University ...

Genes that aid spinal cord healing in lamprey also present in humans

January 15, 2018
Many of the genes involved in natural repair of the injured spinal cord of the lamprey are also active in the repair of the peripheral nervous system in mammals, according to a study by a collaborative group of scientists ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.