Urinary proteomics aids early ID of diabetic nephropathy

August 13, 2012
Urinary proteomics aids early ID of diabetic nephropathy
A biomarker classifier in urine can allow early detection of progression to diabetic nephropathy years before onset of macroalbuminuria, according to a study published online Aug. 7 in Diabetes.

(HealthDay) -- A biomarker classifier in urine can allow early detection of progression to diabetic nephropathy years before onset of macroalbuminuria, according to a study published online Aug. 7 in Diabetes.

Petra Zürbig, Ph.D., from Mosaiques Diagnostics in Hannover, Germany, and colleagues profiled the low-molecular weight proteome in the of 35 patients with type 1 and type 2 using a previously generated biomarker classifier of chronic kidney disease.

The researchers found that, compared with routine diagnosis using urinary albumin, application of the classifier to normoalbuminuric patients up to five years before the onset of macroalbuminuria allowed early detection of subsequent progression to macroalbuminuria (area under the curve, 0.93 versus 0.67). In particular, there was a decrease in collagen fragments three to five years before the development of macroalbuminuria.

"Urinary proteomics enables noninvasive assessment of risk at an early stage via determination of specific collagen fragments," Zürbig and colleagues conclude.

Several authors disclosed financial ties to pharmaceutical companies and/or Mosaiques Diagnostics, which developed and established the capillary electrophoresis coupled to mass spectrometry proteome analysis of human urine.

Explore further: ASMBS: bariatric surgery helps resolve diabetic nephropathy

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

ASMBS: bariatric surgery helps resolve diabetic nephropathy

June 20, 2012

(HealthDay) -- For patients with diabetes who undergo bariatric surgery there is a significant long-term improvement in diabetic nephropathy, according to a study presented at the annual meeting of the American Society for ...

New treatment target for diabetic kidney disease

May 27, 2011

(Medical Xpress) -- UC Davis investigators have shown that blocking a specific receptor pathway could slow or even prevent diabetic nephropathy — an often fatal complication of diabetes for which there are few good treatment ...

Recommended for you

Overweight affects DNA methylation

December 22, 2016

The extra pounds you gain during the holidays will not only show up on your hips but will also affect your DNA. This is the result of a large-scale international study coordinated by Helmholtz Zentrum München, a partner ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.