New guidelines issued for pediatric fever and neutropenia

September 19, 2012
New guidelines issued for pediatric fever and neutropenia
New evidence-based guidelines have been compiled on the management of fever and neutropenia in children with cancer and/or who are undergoing hematopoietic stem-cell transplantation; the guidelines were published online Sept. 17 in the Journal of Clinical Oncology.

(HealthDay)—New evidence-based guidelines have been compiled on the management of fever and and neutropenia (FN) in children with cancer and/or who are undergoing hematopoietic stem-cell transplantation; the guidelines were published online Sept. 17 in the Journal of Clinical Oncology.

Thomas Lehrnbecher, M.D., of the Johann Wolfgang Goethe University in Frankfurt, Germany, and colleagues from the International Pediatric Fever and Neutropenia Guideline Panel followed validated procedures to create evidence-based guidelines for the management of FN in children with cancer and/or undergoing hematopoietic stem-cell transplantation.

Based on the evidence in the literature, summaries were compiled and the evidence graded. The panel made recommendations in the following areas: initial presentation, including , initial evaluation, and treatment; ongoing management, which included cessation of empiric antibiotics; and empiric antifungal treatment for FN, comprising risk stratification, assessment, and treatment.

"This guideline represents an evidence-based approach to FN specific to children with cancer," the authors write. "Although some recommendations are similar to adult-based guidelines, there are key distinctions in multiple areas. Implementation will require adaptation to the local context."

Several authors disclosed to the pharmaceutical industry.

Explore further: New harmonized cardiovascular treatment guidelines make heart disease treatment easier

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

New harmonized cardiovascular treatment guidelines make heart disease treatment easier

September 12, 2011
A new set of harmonized guidelines for the management of risk factors for cardiovascular disease will make it much easier for physicians to care for their patients, according to the authors of the C-CHANGE guidelines published ...

Full weight-Based chemo doses recommended for obese

April 6, 2012
(HealthDay) -- The American Society of Clinical Oncology Clinical Practice Guideline on Appropriate Chemotherapy Dosing for Obese Adult Patients With Cancer recommends using full weight-based cytotoxic chemotherapy doses ...

DMP for diabetes type 2: Current guidelines indicate some need for revision

January 3, 2012
On 3 January 2012, the German Institute for Quality and Efficiency in Health Care (IQWiG) published the results of a literature search for evidence-based clinical practice guidelines on the treatment of people with diabetes ...

IU analysis changing diagnosis and management of initial UTIs in young children

August 30, 2011
Analysis by Indiana University School of Medicine researchers of ten years of scientific studies has resulted in changes in American Academy of Pediatrics recommendations for how initial urinary tract infection in infants ...

Recommended for you

A new weapon against bone metastasis? Team develops antibody to fight cancer

December 11, 2017
In the ongoing battle between cancer and modern medicine, some therapeutic agents, while effective, can bring undesirable or even dangerous side effects. "Chemo saves lives and improves survival, but it could work much better ...

Insights on how SHARPIN promotes cancer progression

December 11, 2017
Researchers at Sanford Burnham Prebys Medical Discovery (SBP) and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one of three proteins in the linear ubiquitin chain assembly complex ...

Glioblastoma survival mechanism reveals new therapeutic target

December 11, 2017
A Northwestern Medicine study, published in the journal Cancer Cell, has provided new insights into a mechanism of tumor survival in glioblastoma and demonstrated that inhibiting the process could enhance the effects of radiation ...

Liver cancer: Lipid synthesis promotes tumor formation

December 11, 2017
Lipids comprise an optimal energy source and an important cell component. Researchers from the Biozentrum of the University of Basel and from the University of Geneva have now discovered that the protein mTOR stimulates the ...

Use of chemotherapy for early stage breast cancer declines, study says

December 11, 2017
A study of nearly 3,000 women with early stage breast cancer indicates a recent, significant decline in the use of chemotherapy despite the lack of any change in national treatment recommendations or guidelines, according ...

Researchers identify epigenetic orchestrator of pancreatic cancer cells

December 11, 2017
Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells' chromatin. The study, which will be published December ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.