New guidelines issued for pediatric fever and neutropenia

September 19, 2012
New guidelines issued for pediatric fever and neutropenia
New evidence-based guidelines have been compiled on the management of fever and neutropenia in children with cancer and/or who are undergoing hematopoietic stem-cell transplantation; the guidelines were published online Sept. 17 in the Journal of Clinical Oncology.

(HealthDay)—New evidence-based guidelines have been compiled on the management of fever and and neutropenia (FN) in children with cancer and/or who are undergoing hematopoietic stem-cell transplantation; the guidelines were published online Sept. 17 in the Journal of Clinical Oncology.

Thomas Lehrnbecher, M.D., of the Johann Wolfgang Goethe University in Frankfurt, Germany, and colleagues from the International Pediatric Fever and Neutropenia Guideline Panel followed validated procedures to create evidence-based guidelines for the management of FN in children with cancer and/or undergoing hematopoietic stem-cell transplantation.

Based on the evidence in the literature, summaries were compiled and the evidence graded. The panel made recommendations in the following areas: initial presentation, including , initial evaluation, and treatment; ongoing management, which included cessation of empiric antibiotics; and empiric antifungal treatment for FN, comprising risk stratification, assessment, and treatment.

"This guideline represents an evidence-based approach to FN specific to children with cancer," the authors write. "Although some recommendations are similar to adult-based guidelines, there are key distinctions in multiple areas. Implementation will require adaptation to the local context."

Several authors disclosed to the pharmaceutical industry.

Explore further: New harmonized cardiovascular treatment guidelines make heart disease treatment easier

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

New harmonized cardiovascular treatment guidelines make heart disease treatment easier

September 12, 2011
A new set of harmonized guidelines for the management of risk factors for cardiovascular disease will make it much easier for physicians to care for their patients, according to the authors of the C-CHANGE guidelines published ...

Full weight-Based chemo doses recommended for obese

April 6, 2012
(HealthDay) -- The American Society of Clinical Oncology Clinical Practice Guideline on Appropriate Chemotherapy Dosing for Obese Adult Patients With Cancer recommends using full weight-based cytotoxic chemotherapy doses ...

DMP for diabetes type 2: Current guidelines indicate some need for revision

January 3, 2012
On 3 January 2012, the German Institute for Quality and Efficiency in Health Care (IQWiG) published the results of a literature search for evidence-based clinical practice guidelines on the treatment of people with diabetes ...

IU analysis changing diagnosis and management of initial UTIs in young children

August 30, 2011
Analysis by Indiana University School of Medicine researchers of ten years of scientific studies has resulted in changes in American Academy of Pediatrics recommendations for how initial urinary tract infection in infants ...

Recommended for you

Poliovirus therapy induces immune responses against cancer

September 20, 2017
An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body's own capacity to fight malignancies by activating an inflammation process that counter's the ability of cancer cells ...

Scientists restore tumor-fighting structure to mutated breast cancer proteins

September 20, 2017
Scientists at the Virginia Tech Carilion Research Institute have successfully determined the full architecture of the breast cancer susceptibility protein (BRCA1) for the first time. This three-dimensional information provides ...

Brain cancer growth halted by absence of protein, study finds

September 20, 2017
The growth of certain aggressive brain tumors can be halted by cutting off their access to a signaling molecule produced by the brain's nerve cells, according to a new study by researchers at the Stanford University School ...

New clinical trial explores combining immunotherapy and radiation for sarcoma patients

September 20, 2017
University of Maryland School of Medicine researchers are investigating a new approach to treat high-risk soft-tissue sarcomas by combining two immunotherapy drugs with radiation therapy to stimulate the immune system to ...

Researchers identify new target, develop new drug for cancer therapies

September 20, 2017
Opening up a new pathway to fight cancer, researchers at the University of Pennsylvania have found a way to target an enzyme that is crucial to tumor growth while also blocking the mechanism that has made past attempts to ...

Targeted antibiotic use may help cure chronic myeloid leukaemia

September 19, 2017
The antibiotic tigecycline, when used in combination with current treatment, may hold the key to eradicating chronic myeloid leukaemia (CML) cells, according to new research.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.