Myogenes identified for spondyloarthritis synovitis

September 27, 2012
Myogenes identified for spondyloarthritis synovitis
There are disease-specific and inflammation-independent stromal alterations in spondyloarthritis synovitis, according to a study published online Sept. 12 in Arthritis & Rheumatism.

(HealthDay)—There are disease-specific and inflammation-independent stromal alterations in spondyloarthritis (SpA) synovitis, according to a study published online Sept. 12 in Arthritis & Rheumatism.

Nataliya Yeremenko, Ph.D., from the University of Amsterdam, and colleagues conducted a synovial gene expression analysis. Pan-genomic microarray (with confirmation by quantitative polymerase chain reaction and immunohistochemistry) was used to analyze synovial tissue biopsies from patients with SpA (63), RA (28), and gout (nine). By stimulating fibroblast-like synoviocytes with synovial fluid and analyzing synovial tissue samples at week zero and 12 of treatment with etanercept, the effect of inflammation on gene expression was evaluated.

The researchers found that microarray analysis identified 64 upregulated transcripts in SpA versus RA synovitis, with a robust myogene signature in this gene set. The myogene signature was specific for SpA and was independent of disease duration, treatment, and SpA subtype. Using synovial staining, the myogene expressing cells were identified as vimentin(+), 4-prolyl-hydroxylase-β(+), CD90(+) and CD146(+) mesenchymal cells. These were significantly overrepresented in the intimal lining layer and synovial sublining of inflamed SpA synovium.

"These data identify a novel and disease-specific myogene signature in SpA synovitis," Yeremenko and colleagues conclude. "The fact that this stromal alteration appeared not to be downstream of local warrants further analysis of its functional role in the disease pathogenesis."

Explore further: Steroids prevent protein changes seen in the joints of people with rheumatoid arthritis

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Cross-species links identified for osteoarthritis

May 17, 2017

New research from the University of Liverpool, published today in the journal npj Systems Biology and Applications, has identified 'cell messages' that could help identify the early stages of osteoarthritis (OA).

Anti-hypertension DASH diet may reduce the risk of gout

May 9, 2017

The results of a study led by Massachusetts General Hospital (MGH) investigators suggest that following a diet known to reduce the risk of hypertension and cardiovascular disease may also reduce the risk of gout. The team's ...

High-fat, high-carb diet a cause of osteoarthritis

April 18, 2017

Saturated fat is a prime suspect in the onset of osteoarthritis after QUT scientists found it changed the composition of cartilage, particularly in the weight-bearing joints of the hip and knee.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.