Sequential oral, topical tacrolimus benefits dermatitis

September 20, 2012
Sequential oral, topical tacrolimus benefits dermatitis
Sequential therapy with oral tacrolimus and topical tacrolimus may be an effective treatment for severe atopic dermatitis, according to a pilot study published in the October issue of the Journal of the American Academy of Dermatology.

(HealthDay)—Sequential therapy with oral tacrolimus and topical tacrolimus may be an effective treatment for severe atopic dermatitis (AD), according to a pilot study published in the October issue of the Journal of the American Academy of Dermatology.

To examine the safety and efficacy of sequential therapy with oral and topical tacrolimus, Terrence Colin Keaney, M.D., from the University of Miami, and colleagues enrolled 12 patients with AD covering at least 50 percent of their body. Over a 14-week period, patients received sequential therapy with oral and topical tacrolimus. At each study visit, the Eczema Area and Severity Index, Physician Global Assessment, and pruritus scores were measured.

The researchers found that, in the Eczema Area and Severity Index score, patients recorded a 67 percent improvement. In the Physician Global Assessment there was a 45 percent improvement recorded, and in the pruritus score a 69 percent reduction was noted.

"In this , treatment of severe AD with oral tacrolimus succeeded in providing quick disease control followed by a successful smooth transition to maintenance with topical tacrolimus 0.1 percent ointment," the authors write.

Two authors disclosed to pharmaceutical companies, including Astellas Pharma, which funded the study.

Explore further: Topical treatment shows potential for infantile eczema

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Topical treatment shows potential for infantile eczema

August 8, 2012
(HealthDay) -- Ten days of treatment with a cream containing 15(R/S)-methyl-lipoxin A4 (LXA4) is well tolerated and reduces the severity of infantile eczema, according to a study published online July 26 in the British Journal ...

Azathioprine may benefit pediatric atopic dermatitis

August 21, 2012
(HealthDay) -- For pediatric patients with refractory atopic dermatitis (AD), oral azathioprine is associated with clinical improvement, and measurement of thiopurine methyltransferase (TPMT) activity seems useful for monitoring ...

Best post-transplant drug regimen identified for patients with new kidneys

July 29, 2011
For the thousands of patients who receive kidney transplants in the United States each year, preventing organ rejection without compromising other aspects of health requires a delicate balance of medications. Immunosuppresive ...

Methotrexate and azathioprine equally efficacious for eczema

April 6, 2012
(HealthDay) -- Methotrexate and azathioprine may be equally effective in treating severe atopic eczema in adults, according to a critical appraisal of a study published in the April issue of the British Journal of Dermatology.

Study examines risk of heart attack associated with various psoriasis treatments

August 20, 2012
Use of tumor necrosis factor (TNF) inhibitors for treatment of psoriasis is associated with a significantly reduced risk for heart attack (myocardial infarction) compared to other forms of treatment, according to a report ...

Substitution of brand name with generic drug proves safe for transplant recipients

September 13, 2011
A new study published in the American Journal of Transplantation reveals that substitution of a brand name immunosuppressive drug with a generic (manufactured by Sandoz) for preventing rejection of transplanted organs appears ...

Recommended for you

H7N9 influenza is both lethal and transmissible in animal model for flu

October 19, 2017
In 2013, an influenza virus that had never before been detected began circulating among poultry in China. It caused several waves of human infection and in late 2016, the number of people to become sick from the H7N9 virus ...

Flu simulations suggest pandemics more likely in spring, early summer

October 19, 2017
New statistical simulations suggest that Northern Hemisphere flu pandemics are most likely to emerge in late spring or early summer at the tail end of the normal flu season, according to a new study published in PLOS Computational ...

New insights into herpes virus could inform vaccine development

October 18, 2017
A team of scientists has discovered new insights into the mechanisms of Epstein-Barr virus (EBV) infection, as well as two antibodies that block the virus' entry into cells. The findings, published in Proceedings of the National ...

Pair of discoveries illuminate new paths to flu and anthrax treatments

October 17, 2017
Two recent studies led by biologists at the University of California San Diego have set the research groundwork for new avenues to treat influenza and anthrax poisoning.

Portable 3-D scanner assesses patients with elephantiasis

October 17, 2017
An estimated 120 million people worldwide are infected with lymphatic filariasis, a parasitic, mosquito-borne disease that can cause major swelling and deformity of the legs, a condition known as elephantiasis. Health-care ...

New tools to combat kidney fibrosis

October 16, 2017
Interstitial fibrosis – excessive tissue scarring – contributes to chronic kidney disease, which is increasing in prevalence in the United States.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.