Metabolic patterns of propofol, sevoflurane differ in children

October 26, 2012
Metabolic patterns of propofol, sevoflurane differ in children
For children undergoing routine anesthesia for medically indicated magnetic resonance imaging, the metabolic signature varies with use of sevoflurane and propofol, according to a study published in the November issue of Anesthesiology.

(HealthDay)—For children undergoing routine anesthesia for medically indicated magnetic resonance imaging (MRI), the metabolic signature varies with use of sevoflurane and propofol, according to a study published in the November issue of Anesthesiology.

Zvi Jacob, M.D., from Stony Brook University in New York, and colleagues used proton magnetic resonance spectroscopy to examine the metabolic consequences of in 59 children undergoing MRI with sevoflurane or propofol. The scans were acquired after about 60 minutes of anesthesia. Upon emergence from anesthesia, the children were evaluated using the pediatric anesthesia emergence delirium scale.

The researchers found that the metabolic signature with sevoflurane anesthesia comprised higher concentrations of lactate and glucose compared with anesthesia using propofol. There was a significant and positive correlation between lactate and glucose with performance on emergence delirium scores, and a negative correlation for total creatine and the emergence delirium score.

"Our results demonstrating higher glucose and lactate with sevoflurane in the compared to propofol could reflect greater with sevoflurane resulting in enhanced glutamate-neurotransmitter cycling, increased glycolysis and lactate shuttling from astrocytes to neurons or mitochondrial dysfunction," the authors write. "Further, the association between emergence delirium and lactate suggests that anesthesia-induced enhanced cortical activity in the unconscious state may interfere with rapid return to 'coherent' brain connectivity patterns required for normal cognition upon emergence of anesthesia."

Explore further: Anesthesia regimen linked to post-orthognathic op pain

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Anesthesia regimen linked to post-orthognathic op pain

July 31, 2012
(HealthDay) -- Patients undergoing orthognathic maxillofacial surgery experience more pain postoperatively if they receive anesthesia with propofol and remifentanil versus inhalational agents and longer-acting opioids, according ...

Recovery from propofol anesthesia may be sped by use of common stimulant

April 5, 2012
The ability of the commonly used stimulant methylphenidate (Ritalin) to speed recovery from general anesthesia appears to apply both to the inhaled gas isoflurane, as previously reported, and to the intravenous drug propofol. ...

Cold-air anesthesia reduces pain of laser treatment

June 22, 2012
(HealthDay) -- In ablative fractionated carbon-dioxide (CO2) laser treatment for photoaging, cold-air anesthesia used in conjunction with topical anesthesia reduces pain significantly more than topical anesthesia alone, according ...

Cognitive deficits seen for infants exposed to anesthesia

August 20, 2012
(HealthDay) -- Anesthesia exposure before the age of 3 years is associated with deficits in language and abstract reasoning in children at age 10, according to a study published online Aug. 20 in Pediatrics.

Recommended for you

Exploring the potential of human echolocation

June 25, 2017
People who are visually impaired will often use a cane to feel out their surroundings. With training and practice, people can learn to use the pitch, loudness and timbre of echoes from the cane or other sounds to navigate ...

Team eradicates hepatitis C in 10 patients following lifesaving transplants from infected donors

April 30, 2017
Ten patients at Penn Medicine have been cured of the Hepatitis C virus (HCV) following lifesaving kidney transplants from deceased donors who were infected with the disease. The findings point to new strategies for increasing ...

'bench to bedside to bench': Scientists call for closer basic-clinical collaborations

March 24, 2017
In the era of genome sequencing, it's time to update the old "bench-to-bedside" shorthand for how basic research discoveries inform clinical practice, researchers from The Jackson Laboratory (JAX), National Human Genome Research ...

The ethics of tracking athletes' biometric data

January 18, 2017
(Medical Xpress)—Whether it is a FitBit or a heart rate monitor, biometric technologies have become household devices. Professional sports leagues use some of the most technologically advanced biodata tracking systems to ...

Financial ties between researchers and drug industry linked to positive trial results

January 18, 2017
Financial ties between researchers and companies that make the drugs they are studying are independently associated with positive trial results, suggesting bias in the evidence base, concludes a study published by The BMJ ...

Best of Last Year – The top Medical Xpress articles of 2016

December 23, 2016
(Medical Xpress)—It was a big year for research involving overall health issues, starting with a team led by researchers at the UNC School of Medicine and the National Institutes of Health who unearthed more evidence that ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.