UC Irvine opens clinical trial of novel treatment for brain cancer

October 10, 2012

UC Irvine doctors are enrolling patients with the deadly brain tumor glioblastoma multiforme in a clinical trial of a vaccine that may prevent the cancer's return or spread after surgery.

"Our goal is to train the immune system to recognize and attack the cancer," said Dr. Daniela Bota, neuro-oncologist and co-director of UC Irvine's Comprehensive Brain Tumor Program. She will lead the Phase II trial at UC Irvine of DCVax, which was associated with increased survival in a previous study.

The vaccine is prepared in a lab and combines protein antigens extracted from the patient's tumor with some of his or her . These grow into dendritic cells that, when injected back into the patient, target the and prompt the immune system's T cells to identify and attack remaining .

"Cancer cells are like crabgrass: Once they take root, they're hard to eradicate, even after brain surgery," Bota said. The current treatment for patients with glioblastoma multiforme involves surgery to remove as much of the tumor as possible, followed by radiation and chemotherapy.

"The standard of care prolongs survival, but it does not fully destroy the cancer," Bota said. She believes the vaccine can help eliminate remaining and further extend patients' lives. Only 10 percent of the 12,000 to 14,000 people annually found to have glioblastoma multiforme survive five years.

Patients 18 to 70 newly diagnosed with this brain tumor (also called grade IV astrocytoma) may be eligible to enroll in the trial. For more information, call UC Irvine toll-free at 877-UCSTUDY (877-827-8839) or email ucstudy@uci.edu. Please refer to protocol UCI-08-16.

Explore further: Novel brain tumor vaccine acts like bloodhound to locate cancer cells

More information: Additional information also is available at clinicaltrials.gov/show/NCT00045968

Related Stories

Novel brain tumor vaccine acts like bloodhound to locate cancer cells

January 5, 2012
A national clinical trial testing the efficacy of a novel brain tumor vaccine has begun at Wake Forest Baptist Medical Center, the only facility in the Southeast to participate.

Lifting the fog: Finding by neuro-oncologist could help eliminate 'chemo brain'

September 29, 2011
After receiving her medical degree in her homeland of Romania, Dr. Daniela Bota came to the U.S. to earn a doctorate in molecular biology to better understand why people develop neurodegenerative diseases such as Alzheimer's.

Researchers study vaccine as potential weapon against aggressive brain tumors

July 24, 2012
Researchers at Northwestern Brain Tumor Institute (NBTI) are seeking to understand if a vaccine made from a patient's own blood cells may slow the growth of a type of brain tumor. The trial is studying the vaccine's effect ...

Immunogene therapy combined with standard treatment is safe for patients with brain tumors

August 15, 2011
A clinical trial has shown that a form of gene therapy is safe for treating a deadly form of brain cancer, even when combined with radiation therapy.

Recommended for you

Researchers develop test that can diagnose two cancer types

December 12, 2017
A blood test using infrared spectroscopy can be used to diagnose two types of cancer, lymphoma and melanoma, according to a study led by Georgia State University.

Atoh1, a potential Achilles' heel of Sonic Hedgehog medulloblastoma

December 12, 2017
Medulloblastoma is the most common type of solid brain tumor in children. Current treatments offer limited success and may leave patients with severe neurological side effects, including psychiatric disorders, growth retardation ...

Cancer-causing mutation suppresses immune system around tumours

December 12, 2017
Mutations in 'Ras' genes, which drive 25% of human cancers by causing tumour cells to grow, multiply and spread, can also protect cancer cells from the immune system, finds a new study from the Francis Crick Institute and ...

Drug suppresses spread of breast cancer caused by stem-like cells

December 12, 2017
Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, ...

MRI scans predict patients' ability to fight the spread of cancer

December 12, 2017
A simple, non-invasive procedure that can indicate how long patients with cancer that has spread to the brain might survive and whether they are likely to respond to immunotherapy has been developed by researchers in Liverpool.

A new weapon against bone metastasis? Team develops antibody to fight cancer

December 11, 2017
In the ongoing battle between cancer and modern medicine, some therapeutic agents, while effective, can bring undesirable or even dangerous side effects. "Chemo saves lives and improves survival, but it could work much better ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.