Scattered X-rays improve early detection of pulmonary disease

October 22, 2012
A combination of dark-field and conventional transmission information allows for a clear distinction of healthy versus emphysematous tissue and an assessment of the regional distribution of the disease. From such images, a doctor might in future not only see if a patient is diseased but also which parts of the lung are affected and how much. Credit: Simone Schleede / Technische Universitaet Muenchen

Severe lung diseases are among the leading causes of death worldwide. To date they have been difficult to diagnose at an early stage. Within an international collaboration scientists from Munich now developed an X-ray technology to do just that. Now they are working on bringing the procedure into medical practice.

(COPD) is considered the fourth most common cause of death in the United States. Usually the precursor to this life-threatening lung disease is a . Partially destroyed alveoli and an over-inflation of the lungs, known as emphysema, are serious side effects. However, the subtle differences in the tissue are barely discernable in standard X-ray images.

In addition to the conventional X-ray images, the Munich scientists analyzed the radiation scattered by the tissue. From these data they calculated detailed images of the lungs of the investigated mice. Using such images, physicians can see not only if a patient is diseased but also how strongly which parts of the lung are affected.

"Especially in early stages of the disease, identification, precise quantification and localization of emphysema through the new technology would be very helpful", says Professor Maximilian Reiser, head of the Institute for at Ludwig-Maximilians-University Munich. "We hope that one day this technology will improve COPD diagnosis and therapy, while avoiding the higher associated with high-resolution CT".

The procedure has been developed as part of the research work of the Cluster of Excellence Munich-Centre for Advanced Photonics (MAP) by physicists from the Technische Universitaet Muenchen (TUM), physicians at the Ludwig-Maximilians-University Munich (LMU) and the Comprehensive Center (CPC) of the Helmholtz Zentrum Muenchen.

For their experiments, the researchers used the Compact Light Source, a compact synchrotron radiation source of Lyncean Technologies Inc. (USA). In the future the Center for Advanced Laser Applications (CALA), a joint project of TUM and LMU on the Research Campus Garching, will develop new laser-driven x-ray sources.

In parallel, the research group led by Franz Pfeiffer, professor for Biomedical Physics at the Technische Universitaet Muenchen, works on the improvement of the x-ray scattering analysis to pave the way for its use with conventional X-ray machines.

More information: Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source. Simone Schleede, Felix G. Meinel, Martin Bech, Julia Herzen, Klaus Achterhold, Guillaume Potdevin, Andreas Malecki, Silvia Adam-Neumair, Sven F. Thieme, Fabian Bamberg, Konstantin Nikolau, Alexander Bohla, Ali Ö. Yildirim, Rod Loewen, Martin Gifford, Ronald Ruth, Oliver Eickelberg, Maximilian Reiser, and Franz Pfeiffer. Proceedings of the National Academy of Sciences, PNAS, Early Edition, 2012, DOI: 10.1073/pnas.1206684109

Related Stories

Recommended for you

Drug found that induces apoptosis in myofibroblasts reducing fibrosis in scleroderma

December 15, 2017
(Medical Xpress)—An international team of researchers has found that the drug navitoclax can induce apoptosis (self-destruction) in myofibroblasts in mice, reducing the spread of fibrosis in scleroderma. In their paper ...

How defeating THOR could bring a hammer down on cancer

December 14, 2017
It turns out Thor, the Norse god of thunder and the Marvel superhero, has special powers when it comes to cancer too.

Researchers track muscle stem cell dynamics in response to injury and aging

December 14, 2017
A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) describes the biology behind why muscle stem cells respond differently to aging or injury. The findings, published in Cell Stem Cell, ...

'Human chronobiome' study informs timing of drug delivery, precision medicine approaches

December 13, 2017
Symptoms and efficacy of medications—and indeed, many aspects of the human body itself—vary by time of day. Physicians tell patients to take their statins at bedtime because the related liver enzymes are more active during ...

Study confirms link between the number of older brothers and increased odds of being homosexual

December 12, 2017
Groundbreaking research led by a team from Brock University has further confirmed that sexual orientation for men is likely determined in the womb.

Potassium is critical to circadian rhythms in human red blood cells

December 12, 2017
An innovative new study from the University of Surrey and Cambridge's MRC Laboratory of Molecular Biology, published in the prestigious journal Nature Communications, has uncovered the secrets of the circadian rhythms in ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.