Cabozantinib active in castration-resistant prostate cancer

December 3, 2012
Cabozantinib active in castration-resistant prostate cancer
The orally bioavailable tyrosine kinase inhibitor cabozantinib (XL184) has clinical activity in men with castration-resistant prostate cancer, according to a study published online Nov. 19 in the Journal of Clinical Oncology.

(HealthDay)—The orally bioavailable tyrosine kinase inhibitor cabozantinib (XL184) has clinical activity in men with castration-resistant prostate cancer (CRPC), according to a study published online Nov. 19 in the Journal of Clinical Oncology.

David C. Smith, M.D., of the University of Michigan in Ann Arbor, and colleagues conducted a phase II randomized discontinuation trial involving 171 men with CRPC to evaluate the activity of cabozantinib. Patients received 100 mg of cabozantinib each day, and those with stable disease at 12-weeks were randomized to receive cabozantinib or placebo.

Based on the observed activity of cabozantinib, random assignment was stopped early. The researchers found that 72 percent of patients had regression in soft tissue lesions and 68 percent exhibited improvement on bone scan, including 12 percent with complete resolution. At 12 weeks, the objective response rate was 5 percent, and 75 percent exhibited stable disease. The median progression-free survival was 23.9 and 5.9 weeks for cabozantinib- and placebo-treated patients, respectively (hazard ratio, 0.12). In 57 percent of patients, there was a reduction of at least 50 percent in serum total and plasma cross-linked C-terminal telopeptide of type I collagen. In a retrospective data review, bone pain was improved for 67 percent of patients, and narcotic use decreased by 56 percent. Fatigue, hypertension, and hand-foot syndrome were the most common grade 3 adverse events.

"Cabozantinib has substantial in patients with advanced CRPC with manageable toxicity consistent with other targeting multiple pathways," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Exelixis, which manufactures cabozantinib and supported the study.

Explore further: Drug shows promise in prostate cancer spread to bone

More information: Abstract
Full Text

Related Stories

Drug shows promise in prostate cancer spread to bone

June 7, 2011
A new drug to treat prostate cancer shows early promise, particularly against tumors that have spread to the bone, a multi-site study shows.

Tivozanib exhibits antitumor activity in renal cancer

April 10, 2012
(HealthDay) -- The potent, selective vascular endothelial growth factor receptor-1, -2, and -3 inhibitor, tivozanib, demonstrates antitumor activity and is well tolerated in patients with advanced/metastatic renal cell carcinoma ...

Vandetanib doesn't up survival in non-small-cell lung cancer

March 2, 2012
(HealthDay) -- Vandetanib does not improve overall survival for patients who have received previous treatment for advanced non-small-cell lung cancer (NSCLC), according to a study published online Feb. 27 in the Journal of ...

Regorafenib active in metastatic GI stromal tumors

May 23, 2012
(HealthDay) -- Regorafenib, an inhibitor of multiple cancer-associated kinases, is active in patients with metastatic gastrointestinal stromal tumors (GIST) who have failed to respond to imatinib and sunitinib, according ...

Cetuximab, paclitaxel combo active in urothelial cancer

August 29, 2012
(HealthDay)—The monoclonal antibody against epidermal growth factor receptor (EGFR), cetuximab, augments the antitumor activity of paclitaxel in patients with previously treated urothelial cancer, according to a study published ...

Ipilimumab active in advanced melanoma with brain mets

March 27, 2012
(HealthDay) -- For some patients with advanced melanoma and brain metastases, ipilimumab is active, according to the results of a phase 2 study published online March 27 in The Lancet Oncology.

Recommended for you

Researchers pinpoint causes for spike in breast cancer genetic testing

October 20, 2017
A sharp rise in the number of women seeking BRCA genetic testing to evaluate their risk of developing breast cancer was driven by multiple factors, including celebrity endorsement, according to researchers at the University ...

Study shows how nerves drive prostate cancer

October 19, 2017
In a study in today's issue of Science, researchers at Albert Einstein College of Medicine, part of Montefiore Medicine, report that certain nerves sustain prostate cancer growth by triggering a switch that causes tumor vessels ...

Gene circuit switches on inside cancer cells, triggers immune attack

October 19, 2017
Researchers at MIT have developed a synthetic gene circuit that triggers the body's immune system to attack cancers when it detects signs of the disease.

One to 10 mutations are needed to drive cancer, scientists find

October 19, 2017
For the first time, scientists have provided unbiased estimates of the number of mutations needed for cancers to develop, in a study of more than 7,500 tumours across 29 cancer types. Researchers from the Wellcome Trust Sanger ...

Researchers target undruggable cancers

October 19, 2017
A new approach to targeting key cancer-linked proteins, thought to be 'undruggable," has been discovered through an alliance between industry and academia.

Suicide molecules kill any cancer cell

October 19, 2017
Small RNA molecules originally developed as a tool to study gene function trigger a mechanism hidden in every cell that forces the cell to commit suicide, reports a new Northwestern Medicine study, the first to identify molecules ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.