PR+ cells add prognostic value in luminal A breast cancer

December 17, 2012
PR+ cells add prognostic value in luminal A breast cancer
Semiquantitative immunohistochemical expression of progesterone receptor-positive tumor cells improves prediction of survival within luminal A breast cancers, according to a study published online Dec. 10 in the Journal of Clinical Oncology.

(HealthDay)—Semiquantitative immunohistochemical expression of progesterone receptor-positive tumor cells improves prediction of survival within luminal A breast cancers, according to a study published online Dec. 10 in the Journal of Clinical Oncology.

Aleix Prat, M.D., from the University of North Carolina at Chapel Hill, and colleagues analyzed gene expression and pathologic features in primary tumors across five independent cohorts to improve current immunohistochemical subtyping of genomically defined luminal A and B subtypes. The researchers derived and independently tested optimal cut-offs of percentage of PR positive tumor cells to predict survival.

The researchers found that in luminal A tumors there were consistently higher rates of PR positivity, human 2 (HER2) negativity, and histologic grade 1, compared to B subtypes. Luminal A tumors also had significantly higher quantitative PR gene and . Independent of endocrine therapy administration, an empiric cut-off of more than 20 percent of PR-positive tumor cells was significant for predicting survival differences within immunohistochemical-defined luminal A tumors. The immunohistochemical 4 score had no additional prognostic value within hormonal receptor (HR) positive/HER2-negative disease when intrinsic immunohistochemical-based subtypes were used that included more than 20 percent PR-positive

"Semiquantitative immunohistochemical expression of PR adds prognostic value within the current immunohistochemical-based luminal A definition by improving the identification of good outcome breast cancers," the authors write. "The new proposed immunohistochemical-based definition of luminal A tumors is HR positive/HER2 negative/Ki-67 less than 14 percent, and PR more than 20 percent."

Several authors disclosed financial ties to BioClassifier.

Explore further: Older patients with certain breast cancer subtype may not benefit from radiation therapy

More information: Abstract
Full Text (subscription or payment may be required)
Editorial

Related Stories

Older patients with certain breast cancer subtype may not benefit from radiation therapy

April 2, 2012
Local breast radiation therapy may not be necessary for women with the luminal A subtype of breast cancer, particularly those aged older than 60, according to study results presented at the AACR Annual Meeting 2012, held ...

Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management

May 3, 2012
American and Spanish researchers have found potential ways for doctors to improve the treatment of hormone receptor-positive breast cancer even if they lack access to costly multi-gene tests, as they report at the 4th IMPAKT ...

Breast cancer recurrence defined by hormone receptor status

October 1, 2012
Human epidermal growth factor (HER2) positive breast cancers are often treated with the same therapy regardless of hormone receptor status. New research published in BioMed Central's open access journal Breast Cancer Research ...

Increased risk for breast cancer death among black women greatest during first 3 years postdiagnosis

October 28, 2012
Non-Hispanic black women diagnosed with breast cancer, specifically those with estrogen receptor-positive tumors, are at a significantly increased risk for breast cancer death compared with non-Hispanic white women.

Pathologic response prediction of survival aided by tumor type

May 30, 2012
(HealthDay) -- Pathologic complete response (pCR) is more highly predictive of recurrence-free survival (RFS) when specific breast cancer tumor type is factored in, according to a study published online May 29 in the Journal ...

Recommended for you

T-cells engineered to outsmart tumors induce clinical responses in relapsed Hodgkin lymphoma

January 16, 2018
WASHINGTON-(Jan. 16, 2018)-Tumors have come up with ingenious strategies that enable them to evade detection and destruction by the immune system. So, a research team that includes Children's National Health System clinician-researchers ...

Researchers identify new treatment target for melanoma

January 16, 2018
Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous ...

More evidence of link between severe gum disease and cancer risk

January 16, 2018
Data collected during a long-term health study provides additional evidence for a link between increased risk of cancer in individuals with advanced gum disease, according to a new collaborative study led by epidemiologists ...

Researchers develop a remote-controlled cancer immunotherapy system

January 15, 2018
A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells.

Dietary fat, changes in fat metabolism may promote prostate cancer metastasis

January 15, 2018
Prostate tumors tend to be what scientists call "indolent" - so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, ...

Pancreatic tumors may require a one-two-three punch

January 15, 2018
One of the many difficult things about pancreatic cancer is that tumors are resistant to most treatments because of their unique density and cell composition. However, in a new Wilmot Cancer Institute study, scientists discovered ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.