Calorie-restricted weight loss restores ghrelin sensitivity

January 21, 2013
Calorie-restricted weight loss restores ghrelin sensitivity
In a mouse model, calorie-restricted weight loss reverses the high-fat diet-induced ghrelin resistance that may contribute to rebound weight gain, according to research published online Jan. 10 in Endocrinology.

(HealthDay)—In a mouse model, calorie-restricted weight loss reverses the high-fat diet-induced ghrelin resistance that may contribute to rebound weight gain, according to research published online Jan. 10 in Endocrinology.

Noting that high-fat diet feeding causes ghrelin resistance in neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons, Dana I. Briggs, Ph.D., of Monash University in Clayton, Australia, and colleagues used a diet-induced obese (DIO) to study the role of ghrelin resistance in diet-induced weight loss and rebound weight gain. DIO mice were allocated to receive chow ad libitum or chow diet with 40 percent until they reached the weight of age-matched lean controls.

The researchers found that body weight, , and plasma insulin all normalized with both dietary interventions. Calorie restriction-induced weight loss correlated with increased plasma ghrelin, restoration of ghrelin sensitivity, and increases in total NPY/AgRP mRNA expression.

"We show that calorie-restricted weight loss after diet-induced obesity restores the ability of ghrelin to induce food intake, indicating a reversal of diet-induced obesity ghrelin resistance with diet-induced weight loss," the authors write. "We suggest long-term diet-induced obesity changes the body weight setpoint, and as the body interprets calorie-restricted weight loss as negative energy balance, ghrelin fights to defend this higher body weight. This represents a novel to restrict rebound weight gain in humans."

Explore further: Anti-obesity vaccine reduces food consumption in animals

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Anti-obesity vaccine reduces food consumption in animals

June 6, 2011
A new therapeutic vaccine to treat obesity by suppressing the appetite-stimulating hormone ghrelin decreases food intake and increases calorie burning in mice, a new study finds. The results will be presented Sunday at The ...

Voluntary exercise by animals prevents weight gain, despite high-fat diet

May 18, 2011
(Medical Xpress) -- University of Cincinnati (UC) researchers have found that animals on a high-fat diet can avoid weight gain if they exercise.

Ratio of appetite-regulating hormones marker of successful dieters

June 25, 2012
A pre-diet measurement of two hormones related to weight regulation can help predict which dieters will be more likely to maintain their weight loss and who will not, according to a new study. The results will be presented ...

Weight gain induced by high-fat diet increases active-period sleep and sleep fragmentation

July 10, 2012
Research to be presented at the Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, finds that prolonged exposure to ...

Recommended for you

Different types of alcohol elicit different emotional responses

November 22, 2017
Different types of alcohol elicit different emotional responses, but spirits are most frequently associated with feelings of aggression, suggests research published in the online journal BMJ Open.

Air pollution linked to poorer quality sperm

November 22, 2017
Air pollution, particularly levels of fine particulate matter (PM2.5), is associated with poorer quality sperm, suggests research published online in Occupational & Environmental Medicine.

Sunrise and sunset guide daily activities of city-dwellers

November 21, 2017
Despite artificial lightning and social conventions, the dynamics of daylight still influence the daily activities of people living in modern, urban environments, according to new research published in PLOS Computational ...

Older men need more protein to maintain muscles

November 21, 2017
The amount of protein recommended by international guidelines is not sufficient to maintain muscle size and strength in older men, according to a new study.

Exercising and eating well are greater contributors to health than standing at work

November 21, 2017
By now you've probably heard the edict from the health community: Sitting is the new smoking. Perhaps you've converted to a standing desk, or maybe you have a reminder on your phone to get up once an hour and walk around ...

Motorcycle crashes cause five times as many deaths as car accidents, six times the health costs

November 20, 2017
Motorcycle accidents are costly in terms of lives and health care costs. Compared with car accidents, motorcycle accidents cause 3 times the injuries, 6 times the medical costs and 5 times the deaths, found new research in ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.