Expression, genomic patterns predict sarcoma progression

January 18, 2013
Expression, genomic patterns predict sarcoma progression
The Complexity Index in Sarcoma and Genomic Index prognostic signatures are valid independent methods of assessing synovial sarcoma prognosis, according to a study published online Jan. 14 in the Journal of Clinical Oncology.

(HealthDay)—The Complexity Index in Sarcoma (CINSARC) and Genomic Index prognostic signatures are valid independent methods of assessing synovial sarcoma (SS) prognosis, according to a study published online Jan. 14 in the Journal of Clinical Oncology.

Pauline Lagarde, of the Institut Bergonié in Bordeaux, France, and colleagues examined whether expression and genomic prognostic signatures related to chromosome integrity in and (CINSARC and Genomic Index) could predict outcomes in SS. In a training/validation approach, 100 patients with primary untreated SS tumors underwent expression and genomic profiling.

The researchers found that CINSARC and Genomic Index exhibited significant independent and validated prognostic values. Fourteen genes in the CINSARC signature were identified through comparing of tumors with or without metastasis; and in an independent cohort, KIF14 and CDCA2, were validated as prognostic markers. Metastasis was associated with genome complexity in both adult and pediatric SS; the adult genome was more frequently rearranged, and, accordingly, metastasis did not develop in pediatric patients who had an even genomic profile.

"To conclude, this study offers results that are meaningful for understanding the metastatic potential of sarcomas in general, and particularly in SS for which this study provides a biologic explanation for the distinct aggressiveness of pediatric and adult SS," the authors write.

Explore further: Gene score IDs prognosis in metastatic neuroblastoma

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Gene score IDs prognosis in metastatic neuroblastoma

August 29, 2012
(HealthDay)—For children with metastatic MYCN-nonamplified neuroblastoma (NBL-NA) diagnosed at age 18 months or older, increased expression of tumor-associated inflammatory genes seems to correlate with poor prognosis, ...

Post-laminectomy spine strength can be predicted

January 17, 2013
(HealthDay)—Following lumbar laminectomy, loss of strength and shear stiffness (SS) can be predicted in the human lumbar spinal segment using measurable parameters, according to a study published in the December issue of ...

PR+ cells add prognostic value in luminal A breast cancer

December 17, 2012
(HealthDay)—Semiquantitative immunohistochemical expression of progesterone receptor-positive tumor cells improves prediction of survival within luminal A breast cancers, according to a study published online Dec. 10 in ...

Telomere failure, telomerase activation drive prostate cancer progression

February 21, 2012
Genomic instability caused by an erosion of the protective caps on chromosomes, followed by activation of an enzyme that reinforces those caps, allows malignant cells to evade destruction and acquire more deadly characteristics, ...

Recommended for you

Researchers release first draft of a genome-wide cancer 'dependency map'

July 27, 2017
In one of the largest efforts to build a comprehensive catalog of genetic vulnerabilities in cancer, researchers from the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute have identified more than 760 genes ...

Cancer-death button gets jammed by gut bacterium

July 27, 2017
Researchers at Michigan Medicine and in China showed that a type of bacterium is associated with the recurrence of colorectal cancer and poor outcomes. They found that Fusobacterium nucleatum in the gut can stop chemotherapy ...

Long-sought mechanism of metastasis is discovered in pancreatic cancer

July 27, 2017
Cells, just like people, have memories. They retain molecular markers that at the beginning of their existence helped guide their development. Cells that become cancerous may be making use of these early memories to power ...

Manmade peptides reduce breast cancer's spread

July 27, 2017
Manmade peptides that directly disrupt the inner workings of a gene known to support cancer's spread significantly reduce metastasis in a mouse model of breast cancer, scientists say.

Blocking the back-door that cancer cells use to escape death by radiotherapy

July 27, 2017
A natural healing mechanism of the body may be reducing the efficiency of radiotherapy in breast cancer patients, according to a new study.

Glowing tumor technology helps surgeons remove hidden cancer cells

July 27, 2017
Surgeons were able to identify and remove a greater number of cancerous nodules from lung cancer patients when combining intraoperative molecular imaging (IMI) - through the use of a contrast agent that makes tumor cells ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.