Palliative radiation use for lung cancer higher than advised

January 18, 2013
Palliative radiation use for lung cancer higher than advised
Half of patients with metastatic non-small-cell lung cancer receive at least one course of palliative radiation therapy, with younger patients and those who received chemotherapy or surgery more likely to receive palliative RT, according to a study published online Jan. 7 in the Journal of Clinical Oncology.

(HealthDay)—Half of patients with metastatic non-small-cell lung cancer (NSCLC) receive at least one course of palliative radiation therapy (RT), with younger patients and those who received chemotherapy or surgery more likely to receive palliative RT, according to a study published online Jan. 7 in the Journal of Clinical Oncology.

Aileen B. Chen, M.D., M.P.P., from the Dana-Farber Cancer Institute in Boston, and colleagues investigated population-based patterns in the use of palliative RT among a cohort of 1,574 patients with metastatic NSCLC, diagnosed from 2003 to 2005, using data from the Outcomes Research and Surveillance Consortium study.

The researchers found that 50 percent of the patients received at least one course of RT, 21 percent received RT to the chest, and 12 percent to the bone. Younger age at diagnosis and receipt of chemotherapy and surgery to metastatic sites were factors associated with the use of palliative RT. Six percent of patients receiving palliative bone RT received single-fraction treatment, while 42 percent of those receiving palliative chest RT received more than 20 fractions. Lower doses and fewer fractions to the bone and chest were more likely among patients treated in integrated networks.

"When palliative RT is used in patients with metastatic NSCLC, a substantial proportion of patients receive a greater number of treatments and higher doses than supported by current evidence, suggesting an opportunity to improve care delivery," Chen and colleagues conclude.

One author disclosed to WellPoint.

Explore further: Many mistakenly think radiation might cure terminal lung cancer

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Many mistakenly think radiation might cure terminal lung cancer

October 29, 2012
(HealthDay)—Many people with incurable lung cancer mistakenly believe that radiation therapy meant to ease their pain and other symptoms may cure their disease, researchers report.

Patient preference doesn't affect chemo in advanced CRC

September 21, 2012
(HealthDay)—For patients with metastatic colorectal cancer (mCRC), most patients are treated with chemotherapy, even if they express negative or marginal preferences, according to a study published online Sept. 12 in Cancer.

Tricuspid regurgitant jet velocity up in childhood cancer survivors

January 18, 2013
(HealthDay)—About one-quarter of adult survivors of childhood cancer who received chest-directed radiation therapy (RT) have increased tricuspid regurgitant jet velocity (TRV), according to research published online Jan. ...

Recommended for you

Shooting the achilles heel of nervous system cancers

July 20, 2017
Virtually all cancer treatments used today also damage normal cells, causing the toxic side effects associated with cancer treatment. A cooperative research team led by researchers at Dartmouth's Norris Cotton Cancer Center ...

Molecular changes with age in normal breast tissue are linked to cancer-related changes

July 20, 2017
Several known factors are associated with a higher risk of breast cancer including increasing age, being overweight after menopause, alcohol intake, and family history. However, the underlying biologic mechanisms through ...

Immune-cell numbers predict response to combination immunotherapy in melanoma

July 20, 2017
Whether a melanoma patient will better respond to a single immunotherapy drug or two in combination depends on the abundance of certain white blood cells within their tumors, according to a new study conducted by UC San Francisco ...

Discovery could lead to better results for patients undergoing radiation

July 19, 2017
More than half of cancer patients undergo radiotherapy, in which high doses of radiation are aimed at diseased tissue to kill cancer cells. But due to a phenomenon known as radiation-induced bystander effect (RIBE), in which ...

Definitive genomic study reveals alterations driving most medulloblastoma brain tumors

July 19, 2017
The most comprehensive analysis yet of medulloblastoma has identified genomic changes responsible for more than 75 percent of the brain tumors, including two new suspected cancer genes that were found exclusively in the least ...

Novel CRISPR-Cas9 screening enables discovery of new targets to aid cancer immunotherapy

July 19, 2017
A novel screening method developed by a team at Dana-Farber/Boston Children's Cancer and Blood Disorders Center—using CRISPR-Cas9 genome editing technology to test the function of thousands of tumor genes in mice—has ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.