Intensive glucose control improves CVD risk factors

April 15, 2013
Intensive glucose control improves CVD risk factors
Intensive glucose-lowering therapy is associated with favorable changes in lipoprotein levels and inflammatory risk factors even though it does not lower the incidence of cardiovascular events, according to a study published online March 27 in Diabetes Care.

(HealthDay)—Intensive glucose-lowering therapy (INT) is associated with favorable changes in lipoprotein levels and inflammatory risk factors even though it does not lower the incidence of cardiovascular events, according to a study published online March 27 in Diabetes Care.

Juraj Koska, M.D., from the Phoenix Veterans Affairs Health Care System, and colleagues analyzed standard plasma lipids, cholesterol content of lipoprotein subfractions, and plasma inflammatory and prothrombotic markers in 266 participants of the Veterans Affairs Diabetes Trial. Measurements were taken at baseline and following nine months of either INT or standard therapy.

The researchers found that INT significantly lowered glycated hemoglobin compared to standard treatment (median reduction 2 percent versus 0.7 percent, respectively). INT also significantly increased BMI (4 versus 1 percent), total HDL (9 versus 4 percent), HDL2 (14 versus 0 percent), LDL2 (36 versus 1 percent), and plasma adiponectin (130 versus 80 percent). There were also significant reductions in triglycerides (213 versus 24 percent) and small, dense LDL4 (239 versus 213 percent). INT had no effect on levels of plasma apolipoproteins B-100 and B-48, C-reactive protein, interleukin-6, lipoprotein-associated phospholipase A2, myeloperoxidase, , and plasminogen activator inhibitor 1. Baseline interleukin-6 (hazard ratio per each quartile increase, 1.33), total LDL (1.25), apolipoprotein B-100 (1.29), and fibrinogen (1.26) were associated with incident macrovascular events but not changes in any at 9 months

"INT was associated with improved adiponectin, , and a favorable shift in LDL and HDL subfractions after nine months," the authors write.

Explore further: Non-HDL-C level associated with risk of major cardiovascular events among patients taking statins

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Non-HDL-C level associated with risk of major cardiovascular events among patients taking statins

March 27, 2012
Levels of non-high-density lipoprotein cholesterol (non-HDL-C) among statin-treated patients appears to be associated with the risk of developing a major cardiovascular event, such as a heart attack or stroke, as are levels ...

Clopidogrel after MI less effective in diabetes patients

September 5, 2012
(HealthDay)—Clopidogrel therapy following a heart attack does less to reduce the risk of death in patients with diabetes than in those without diabetes, according to a study published in the Sept. 5 issue of the Journal ...

Exercise stimulates adiponectin, raises HDL levels

October 18, 2012
(HealthDay)—Intensive lifestyle intervention for weight loss (ILI) significantly improves high-density lipoprotein cholesterol (HDL-C) levels in overweight and obese individuals with type 2 diabetes, which is partially ...

Lipid-related markers addition linked with slight improvement in cardiovascular disease prediction

June 19, 2012
Among individuals without known cardiovascular disease (CVD), the addition of certain apolipoproteins and lipoproteins to risk scores containing total cholesterol and high-density lipoprotein cholesterol (HDL-C) was associated ...

Peer coaching model beneficial for patients with diabetes

April 3, 2013
(HealthDay)—Health coaching by peers is associated with a significant reduction in hemoglobin A1c (HbA1c) levels among patients treated in public health clinics, according to research published in the March/April issue ...

Primary care model ups African Americans' glycemic control

April 5, 2013
(HealthDay)—A primary care strategy targeting rural, low-income, African-American patients with type 2 diabetes is associated with improved glycemic control, according to research published in March/April issue of the ...

Recommended for you

Scientists discover a new way to treat type 2 diabetes

July 21, 2017
Medication currently being used to treat obesity is also proving to have significant health benefits for patients with type 2 diabetes. A new study published today in Molecular Metabolism explains how this therapeutic benefit ...

Alzheimer's drug cuts hallmark inflammation related to metabolic syndrome by 25 percent

July 20, 2017
An existing Alzheimer's medication slashes inflammation and insulin resistance in patients with metabolic syndrome, a potential therapeutic intervention for a highly dangerous condition affecting 30 percent of adults in the ...

Diabetes or its precursor affects 100 million Americans

July 19, 2017
Almost one-third of the US population—100 million people—either has diabetes or its precursor condition, known as pre-diabetes, said a government report Tuesday.

One virus may protect against type 1 diabetes, others may increase risk

July 11, 2017
Doctors can't predict who will develop type 1 diabetes, a chronic autoimmune disease in which the immune system destroys the cells needed to control blood-sugar levels, requiring daily insulin injections and continual monitoring.

Diabetes complications are a risk factor for repeat hospitalizations, study shows

July 7, 2017
For patients with diabetes, one reason for hospitalization and unplanned hospital readmission is severe dysglycemia (uncontrolled hyperglycemia - high blood sugar, or hypoglycemia - low blood sugar), says new research published ...

Researchers identify promising target to protect bone in patients with diabetes

July 7, 2017
Utilizing metabolomics research techniques, NYU Dentistry researchers investigated the underlying biochemical activity and signaling within the bone marrow of hyperglycemic mice with hopes of reducing fracture risks of diabetics

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.