Reducing experimental inflammatory arthritis

May 24, 2013, University College Dublin

(Medical Xpress)—UCD researchers led by Conway Fellow, Professor David Brayden in UCD School of Veterinary Medicine have successfully reduced inflammation in the swollen arthritic knees of a murine model using a novel nanoparticle.

The team used an anti-inflammatory molecule complexed in a nanoparticle of to overcome the body's normal clearing processes.

In addition to reducing inflammation after a localised injection of this new nanoparticle preparation, the team identified the inflammatory receptor target for the components of the particle and demonstrated its reduction.

"By using these molecules in a 'nano' format, we were able to successfully target the site of inflammation and retain them there to reduce swelling. The effect compared favourably to treatment with steroids", said Prof Brayden. "This may provide a new type of long-acting, 'nano' therapy for human or animals suffering with in the future".

This condition has a huge social impact for the aging Western population with the (WHO) reporting 10% of men and 18% of women aged over 60 have symptomatic osteoarthritis (OA). The WHO estimates that 80% of those have limitations in movement and 25% cannot perform major daily activities.

Explore further: A new 'on' signal for inflammation

More information: Ryan, S. et al. An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis, Journal of Controlled Release (2013) 167: 120-129 Feb 4.

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