Overinterpretation common in diagnostic accuracy studies

May 15, 2013
Overinterpretation common in diagnostic accuracy studies
Roughly three in 10 diagnostic accuracy studies published in journals with impact factors of four or higher have overinterpretation, according to a review published in the May issue of Radiology.

(HealthDay)—Roughly three in 10 diagnostic accuracy studies published in journals with impact factors of four or higher have overinterpretation, according to a review published in the May issue of Radiology.

Eleanor A. Ochodo, M.B.Ch.B., from University of Amsterdam, and colleagues conducted a literature review to identify diagnostic accuracy studies published between January and June 2010 in journals with an of four or higher. Primary studies of the accuracy of one or more tests compared with a clinical reference standard were included.

The researchers found that 39 of 126 studies (31 percent) contained a form of actual overinterpretation, including 29 (23 percent) with an overly optimistic abstract, 10 (8 percent) with a between the study aim and conclusion, and eight with conclusions based on selected subgroups. Authors of 89, 88, and 57 percent of the studies, respectively, did not include a sample size calculation, did not state a test hypothesis, and did not report confidence intervals of accuracy measurements, all demonstrating potential overinterpretation. Analyzing a subgroup of imaging studies found that 16 (30 percent) and 53 (100 percent) contained forms of actual and potential overinterpretation, respectively.

"Overinterpretation and misreporting of results in studies is frequent in journals with high impact factors," the authors write.

Explore further: Standard criteria needed for spinal stenosis diagnosis

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Standard criteria needed for spinal stenosis diagnosis

April 28, 2013
(HealthDay)—There is a need for a consensus on criteria to define and classify lumbar spinal stenosis, according to a review published in the April 15 issue of Spine.

Tomosynthesis ups accuracy of digital mammography

January 4, 2013
(HealthDay)—Using a combination of tomosynthesis, which produces a three-dimensional reconstruction of the breast, with digital mammography increases radiologists' diagnostic accuracy and significantly lowers the number ...

Recent improvement in 3D ECHO accuracy for LV mass

May 3, 2012
(HealthDay) -- In the past decade there has been an improvement in the accuracy of three-dimensional echocardiography (3DE) for measurement of left ventricular (LV) mass, according to a meta-analysis published online April ...

Specificity up with stereoscopic mammography for CA detection

January 18, 2013
(HealthDay)—Three-dimensional stereoscopic digital mammography (DM) significantly improves the specificity and accuracy of breast cancer detection, with a lower patient recall rate and a sensitivity comparable to that of ...

Tests don't predict outcome after spine fusion for back pain

November 15, 2012
(HealthDay)—Currently, there is no test available to reliably predict which patients with chronic low back pain (LBP) will achieve a good clinical outcome after spinal fusion surgery, according to the results of a literature ...

Benefit of PET or PET/CT in bone and soft tissue tumors is not proven

March 7, 2013
For patients with bone and soft tissue tumours, the study data currently available allow no robust conclusions as to the advantages and disadvantages of using positron emission tomography (PET), alone or in combination with ...

Recommended for you

Single blood test screens for eight cancer types

January 18, 2018
Johns Hopkins Kimmel Cancer Center researchers developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer.

How cancer metastasis happens: Researchers reveal a key mechanism

January 18, 2018
Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial ...

Researchers find a way to 'starve' cancer

January 18, 2018
Researchers at Vanderbilt University Medical Center (VUMC) have demonstrated for the first time that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital ...

These foods may up your odds for colon cancer

January 18, 2018
(HealthDay)—Chowing down on red meat, white bread and sugar-laden drinks might increase your long-term risk of colon cancer, a new study suggests.

The pill lowers ovarian cancer risk, even for smokers

January 18, 2018
(HealthDay)—It's known that use of the birth control pill is tied to lower odds for ovarian cancer, but new research shows the benefit extends to smokers or women who are obese.

Modular gene enhancer promotes leukemia and regulates effectiveness of chemotherapy

January 18, 2018
Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in cancer. Scientists from the German Cancer Research ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.