Impaired sleep ups risk of relapse in Crohn's disease

August 8, 2013
Impaired sleep ups risk of relapse in crohn's disease
For patients with Crohn's disease, but not ulcerative colitis, sleep impairment is associated with increased risk of relapse, according to a study published in the August issue Clinical Gastroenterology and Hepatology.

(HealthDay)—For patients with Crohn's disease (CD), but not ulcerative colitis, sleep impairment is associated with increased risk of relapse, according to a study published in the August issue Clinical Gastroenterology and Hepatology.

In an effort to examine the role of sleep disturbance on the risk of relapse, Ashwin N. Ananthakrishnan, M.D., M.P.H., from Massachusetts General Hospital in Boston, and colleagues analyzed data from 3,173 patients with (IBD; 1,798 in clinical remission at baseline) participating in a longitudinal, Internet-based cohort.

The researchers found that correlates of sleep disturbance at enrollment included disease activity, depression, female gender, smoking, and use of corticosteroids or narcotics. Of the 1,291 patients whose CD was in remission at baseline, the risk of active disease at six months was increased two-fold for those with impaired sleep (adjusted odds ratio, 2.00). This association was not seen for patients with ulcerative colitis. The results were consistent in different sensitivity analyses.

"In conclusion, we identified sleep impairment during remission to be a risk factor for disease flares in CD in a large IBD cohort," the authors write. "There is a need for further research on the potential benefits of routine assessment of sleep quality as well as intervention-based studies to improve sleep quality in patients with CD, which ultimately may impact ."

Explore further: Depressive symptoms tied to doubled risk for Crohn's

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Depressive symptoms tied to doubled risk for Crohn's

January 16, 2013
(HealthDay)—Depressive symptoms are associated with a two-fold increase in risk of Crohn's disease (CD) but not ulcerative colitis (UC), according to research published in the January issue of Clinical Gastroenterology ...

Ulcerative colitis, not crohn's, deaths down from 1982

January 21, 2013
(HealthDay)—Over the past 30 years in Denmark, mortality from ulcerative colitis (UC) has decreased, but mortality from Crohn's disease (CD) has remained persistently higher than the general population, according to research ...

Inflammatory bowel disease raises risk of melanoma

May 20, 2013
Patients with inflammatory bowel disease (IBD) are at higher risk of melanoma, a form of skin cancer, report researchers at Mayo Clinic. Researchers found that IBD is associated with a 37 percent greater risk for the disease. ...

Study finds dramatic increase in hospitalization of US children with inflammatory bowel disease

June 25, 2013
The largest investigation to date has found a dramatic increase in the number of hospitalizations for children with inflammatory bowel disease (IBD) during the past decade in the United States.

New research suggests glaucoma screenings for sleep apnea sufferers

August 7, 2013
August 7, 2013 – Researchers in Taiwan have discovered that people with sleep apnea are far more likely to develop glaucoma compared to those without the sleep condition. The results of this study, which is the first to ...

Sleep problems may increase risk for prostate cancer

May 7, 2013
Men who reported sleep problems, including difficulty falling asleep and staying asleep, had up to a twofold increased risk for prostate cancer, according to data published in Cancer Epidemiology, Biomarkers & Prevention, ...

Recommended for you

Anti-malaria drug shows promise as Zika virus treatment

November 17, 2017
A new collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego School of Medicine has found that a medication used to prevent and treat malaria may also be effective ...

Scientists identify biomarkers that indicate likelihood of survival in infected patients

November 17, 2017
Scientists have identified a set of biomarkers that indicate which patients infected with the Ebola virus are most at risk of dying from the disease.

Research team unlocks secrets of Ebola

November 16, 2017
In a comprehensive and complex molecular study of blood samples from Ebola patients in Sierra Leone, published today (Nov. 16, 2017) in Cell Host and Microbe, a scientific team led by the University of Wisconsin-Madison has ...

Study raises possibility of naturally acquired immunity against Zika virus

November 16, 2017
Birth defects in babies born infected with Zika virus remain a major health concern. Now, scientists suggest the possibility that some women in high-risk Zika regions may already be protected and not know it.

A structural clue to attacking malaria's 'Achilles heel'

November 16, 2017
Researchers from The Scripps Research Institute (TSRI) and PATH's Malaria Vaccine Initiative (MVI) have shed light on how the human immune system recognizes the malaria parasite though investigation of antibodies generated ...

Molecular pathway offers treatment targets for pulmonary fibrosis, related conditions

November 15, 2017
A study led by investigators at Massachusetts General Hospital (MGH) and University Health Network (UHN) in Toronto has identified a molecular pathway that appears to be critical to the development of fibrosis - scarring ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.