Iron status predicts prognosis in patients with T2DM, CAD

November 5, 2013
Iron status predicts prognosis in patients with T2DM, CAD

(HealthDay)—Iron status can independently predict long-term outcomes in patients with type 2 diabetes and coronary artery disease (CAD), according to a study published online Oct. 15 in Diabetes Care.

Beata Ponikowska, M.D., Ph.D., from Wroclaw Medical University in Poland, and colleagues measured serum ferritin, transferrin saturation, and soluble transferrin receptor (sTfR) in 287 with type 2 diabetes and stable CAD (average age, 65 years; 78 percent men). Participants were followed for a mean of 45 months.

The researchers found that, during the study period, 21 percent of patients died and 21 percent had cardiovascular hospitalizations. The five-year all-cause mortality rates were strongly predicted by both serum ferritin and sTfR, independent of other variables (including hemoglobin, measures of renal function, inflammation, and neurohormonal activation). The relationship between sTfR and mortality was exponential (adjusted hazard ratio [HR] per 1 log mg/L, 4.24; P = 0.01), while a U-shaped relationship was seen for ferritin and mortality (for the lowest and the highest quintiles versus the middle quintile, respectively: adjusted HRs, 7.18 and 5.12).

"Both low and high (possibly reflecting depleted and excessive iron stores, respectively) along with high serum sTfR (reflecting reduced metabolically available iron) identify patients with type 2 and CAD who have a poor prognosis," the authors conclude.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Researchers iron out the link between serum ferritin and diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Researchers iron out the link between serum ferritin and diabetes

September 10, 2012
Iron overload increases the risk for insulin resistance and type 2 diabetes; however, the exact mechanisms that link the two are unknown.

Longer breastfeeding duration boosts risk of iron deficiency

April 17, 2013
(HealthDay)—Longer breastfeeding duration is associated with increased odds of iron deficiency in healthy children, according to a study published online April 15 in Pediatrics.

Skin intrinsic fluorescence tied to coronary artery disease

August 7, 2012
(HealthDay) -- Skin intrinsic fluorescence (SIF) is significantly associated with coronary artery disease (CAD) in middle-aged adults with a long duration of type 1 diabetes, according to a study published online July 30 ...

Clopidogrel after MI less effective in diabetes patients

September 5, 2012
(HealthDay)—Clopidogrel therapy following a heart attack does less to reduce the risk of death in patients with diabetes than in those without diabetes, according to a study published in the Sept. 5 issue of the Journal ...

Metformin may increase risk of cognitive impairment

September 21, 2013
(HealthDay)—Metformin may increase the risk of cognitive impairment in patients with diabetes; however, calcium supplementation may attenuate this risk, according to research published online Sept. 5 in Diabetes Care.

In CAD, highest mortality risk for central obesity, normal BMI

January 29, 2013
(HealthDay)—For individuals with coronary artery disease (CAD), central obesity in combination with normal weight is associated with the highest risk of mortality, according to research published in the Feb. 5 issue of ...

Recommended for you

Screen time linked to diabetes

July 28, 2017
Daily screen time of three or more hours is linked to several risk factors associated with the development of diabetes in children, according to a study by St George's, University of London.

People who drink 3 to 4 times per week less likely to develop diabetes than those who never drink: study

July 27, 2017
Frequent alcohol consumption is associated with a reduced risk of diabetes in both men and women, according to a new study published in Diabetologia (the journal of the European Association for the Study of Diabetes), with ...

Diabetes can be tracked with our Google searches

July 26, 2017
The emergence of Type 2 Diabetes could be more effectively monitored using our Google searches—helping public health officials keep track of the disease and halt its spread—according to research by the University of Warwick.

Scientists discover a new way to treat type 2 diabetes

July 21, 2017
Medication currently being used to treat obesity is also proving to have significant health benefits for patients with type 2 diabetes. A new study published today in Molecular Metabolism explains how this therapeutic benefit ...

Alzheimer's drug cuts hallmark inflammation related to metabolic syndrome by 25 percent

July 20, 2017
An existing Alzheimer's medication slashes inflammation and insulin resistance in patients with metabolic syndrome, a potential therapeutic intervention for a highly dangerous condition affecting 30 percent of adults in the ...

Diabetes or its precursor affects 100 million Americans

July 19, 2017
Almost one-third of the US population—100 million people—either has diabetes or its precursor condition, known as pre-diabetes, said a government report Tuesday.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.