Researcher to grow human cells in space to test treatment for stroke

December 19, 2013

Abba Zubair, M.D., Ph.D, believes that cells grown in the International Space Station (ISS) could help patients recover from a stroke, and that it may even be possible to generate human tissues and organs in space. He just needs a chance to demonstrate the possibility.

He now has it. The Center for the Advancement of Science in Space (CASIS), a that promotes research aboard the ISS, has awarded Dr. Zubair a $300,000 grant to send human stem cells into space to see if they grow more rapidly than stem cells grown on Earth.

Dr. Zubair, medical and scientific director of the Cell Therapy Laboratory at Mayo Clinic in Florida, says the experiment will be the first one Mayo Clinic has conducted in space and the first to use these human stem cells, which are found in bone marrow.

"On Earth, we face many challenges in trying to grow enough stem cells to treat patients," he says. "It now takes a month to generate enough cells for a few patients. A clinical-grade laboratory in space could provide the answer we all have been seeking for regenerative medicine."

He specifically wants to expand the population of stem cells that will induce regeneration of neurons and blood vessels in patients who have suffered a , the kind of stroke which is caused by blood clot. Dr. Zubair already grows such cells in his Mayo Clinic laboratory using a large tissue culture and several incubators—but only at a snail's pace.

Experiments on Earth using microgravity have shown that —the that produce all organ and tissue cell types—will grow faster, compared to conventionally grown cells.

"If you have a ready supply of these cells, you can treat almost any condition, and can theoretically regenerate entire organs using a scaffold," Dr. Zubair says. "Additionally, they don't need to come from individual patients—anyone can use them without rejection."

Dr. Zubair is working with engineers at the University of Colorado who are building the specialized cell bioreactor that will be taken to the ISS within a year for the experiment.

"I don't really think growing cells in space for clinical use on Earth is science fiction," he says. "Commercial flights to the ISS will start soon, and the cost of traveling there is coming down. We just need to show what can be achieved in space, and this award from CASIS helps us do that."

Explore further: Regenerative medicine: Researchers develop new tool for transplanting stem cells

Related Stories

Regenerative medicine: Researchers develop new tool for transplanting stem cells

December 16, 2013
Mayo Clinic researchers and colleagues in Belgium have developed a specialized catheter for transplanting stem cells into the beating heart. The novel device includes a curved needle and graded openings along the needle shaft, ...

How prostate cancer cells evolve

December 4, 2013
(Medical Xpress)—UCLA researchers have discovered how prostate cancer stem cells evolve as the disease progresses, a finding that could help point the way to more highly targeted therapies. 

Stem cells could set up future transplant therapies

October 31, 2013
(Medical Xpress)—Scientists have developed a new method for creating stem cells for the human liver and pancreas. This method could enable both cell types to be grown in sufficient quantities for clinical use.

New way to weed out problem stem cells, making therapy safer

September 27, 2012
Mayo Clinic researchers have found a way to detect and eliminate potentially troublemaking stem cells to make stem cell therapy safer. Induced Pluripotent Stem cells, also known as iPS cells, are bioengineered from adult ...

Adult stem cells help build human blood vessels in engineered tissues

October 14, 2013
(Medical Xpress)—Researchers at the University of Illinois at Chicago have identified a protein expressed by human bone marrow stem cells that guides and stimulates the formation of blood vessels.

Recommended for you

Link between cells associated with aging and bone loss

August 21, 2017
Mayo Clinic researchers have reported a causal link between senescent cells - the cells associated with aging and age-related disease - and bone loss in mice. Targeting these cells led to an increase in bone mass and strength. ...

Are stem cells the link between bacteria and cancer?

August 17, 2017
Gastric carcinoma is one of the most common causes of cancer-related deaths, primarily because most patients present at an advanced stage of the disease. The main cause of this cancer is the bacterium Helicobacter pylori, ...

Two-step process leads to cell immortalization and cancer

August 17, 2017
A mutation that helps make cells immortal is critical to the development of a tumor, but new research at the University of California, Berkeley suggests that becoming immortal is a more complicated process than originally ...

New Pathology Atlas maps genes in cancer to accelerate progress in personalized medicine

August 17, 2017
A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of their corresponding protein levels for overall patient survival. The difference in expression patterns ...

Female mouse embryos actively remove male reproductive systems

August 17, 2017
A protein called COUP-TFII determines whether a mouse embryo develops a male reproductive tract, according to researchers at the National Institutes of Health and their colleagues at Baylor College of Medicine, Houston. The ...

New technique overcomes genetic cause of infertility

August 17, 2017
Scientists have created healthy offspring from genetically infertile male mice, offering a potential new approach to tackling a common genetic cause of human infertility.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.