Microbiologist helps reveal how helper T-cells learn their function

February 14, 2014, Brigham Young University
BYU professor of microbiology and molecular biology, Scott Weber, works in the lab.

(Medical Xpress)—When people get sick, their body's immune system launches a counter attack to protect the body. An important part of succeeding in that battle involves the work of helper T-cells.

Scientists know that some of those helper T-cells are more effective than others and new research coauthored by a BYU microbiologist appearing in Nature Immunology has found out why: Some helper T-cells do better in school.

"The early education that helper T-cells get has a surprising effect on how successful they'll be in protecting the body," said Scott Weber, BYU professor of Microbiology and Molecular biology. "With this work we've discovered new insights into how a T-cell is educated."

The study is published in a top-tier journal in the field of immunology and could ultimately have significant impact on the development of vaccines. This research joins other studies taking place at BYU that are helping improve treatment and diagnosis in the fields of cancer, Alzheimer's and other diseases.

BYU's commitment to making significant advances in science research is as strong as ever, as evidenced by the new 265,000-square-foot Life Sciences Building set to open this year. Weber and his fellow biologists will move into the building this summer and take advantage of the state-of-the-art labs in their continued pursuits of high-profile scientific discovery, and in Weber's case, improving immunity to infection.

"If we can understand how to improve T-cell function, we can design vaccines for specific infectious agents that provide better helper T-cell stimulation," said Weber, who earned his Ph.D. from the University of Illinois. "This would help, particularly in young people, improve T-cells so that they function better long term."

The "early education" of T-cells Weber mentioned is a two-part process the immune-system cells experience in the thymus (a small organ above the heart) before they are released: First, in order to function properly they must be able to recognize and bind to small proteins presented by thymic cells. Second, they must not bind too strongly to the proteins presented by these thymic cells to prevent autoimmunity.

Past research has understood this process as a pass/fail exam: accomplish both or the T-cell dies. But Weber and his team have found some T-cells are getting better grades during this education process than others, and thus, are performing their jobs better.

"What was once considered a process only important in determining if a T-cell survives or not is much more important. These interactions a T-cell has in the thymus are actually determining how well they respond to infection later in development," Weber said. "The early interactions in the thymus are deciding the T-cells' fate; they're deciding the type of T-cells they'll become and how well they will protect the body from infection."

To determine this, Weber and his team looked at how two specific lines of T-cells in mice responded to the introduction of a virulent food-borne pathogen. Their study found that when T-cells are deprived of these early interactions with self-peptide their response to infection was negatively affected.

Even more surprisingly, the researchers found that the T-cells didn't need to interact with a foreign pathogen to exhibit their differences. The cells showed intrinsic differences before coming into contact with bacteria.

"If they received a good education, even before they saw a pathogen, there was something inherently different about them," Weber said. "It's really all about the value of education and its ability to cause long term change."

Explore further: Explainer: What is the immune system?

More information: "Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC." Stephen P Persaud, Chelsea R Parker, Wan-Lin Lo,K Scott Weber, Paul M Allen, Nature Immunology (2014) DOI: 10.1038/ni.2822. Received 13 September 2013 Accepted 20 December 2013 Published online 02 February 2014

Related Stories

Explainer: What is the immune system?

January 8, 2014
The immune system is an integral part of our body, keeping us safe from diseases – from the common cold to more severe illnesses such as cancer.

Protein serves as a natural boost for immune system fight against tumors

January 30, 2014
Substances called adjuvants that enhance the body's immune response are critical to getting the most out of vaccines. These boosters stimulate the regular production of antibodies—caused by foreign substances in the body—toxins, ...

Penn researchers describe key molecule that keeps immune cell development on track

August 8, 2011
In the latest issue of Nature, researchers at the Perelman School of Medicine at the University of Pennsylvania clarify the role of two proteins key to T-cell development. They found that one well-known protein called Notch ...

Origin of unusual glands in the body discovered

January 23, 2014
The thymus gland is a critical component of the human immune system that is responsible for the development of T-lymphocytes, or T-cells, which help organize and lead the body's fighting forces against harmful organisms like ...

Salmonella infection mitigates asthma

January 23, 2014
Researchers from Germany have identified the mechanism by which Salmonella infections can reduce the incidence of asthma in mice. The research, which appears ahead of print in the journal Infection and Immunity, opens up ...

Rare immune cells could hold key to treating immune disorders

April 2, 2012
The characterisation of a rare immune cell's involvement in antibody production and ability to 'remember' infectious agents could help to improve vaccination and lead to new treatments for immune disorders, say researchers ...

Recommended for you

Improving vaccines for the elderly by blocking inflammation

January 22, 2018
By identifying why skin immunity declines in old age, a UCL-led research team has found that an anti-inflammatory pill could help make vaccines more effective for elderly people.

Novel genomic tools provide new insight into human immune system

January 19, 2018
When the body is under attack from pathogens, the immune system marshals a diverse collection of immune cells to work together in a tightly orchestrated process and defend the host against the intruders. For many decades, ...

Genomics reveals key macrophages' involvement in systemic sclerosis

January 18, 2018
A new international study has made an important discovery about the key role of macrophages, a type of immune cell, in systemic sclerosis (SSc), a chronic autoimmune disease which currently has no cure.

First vaccine developed against grass pollen allergy

January 18, 2018
Around 400 million people worldwide suffer in some form or other from a grass pollen allergy (rhinitis), with the usual symptoms of runny nose, cough and severe breathing problems. In collaboration with the Viennese firm ...

Researchers discover key driver of atopic dermatitis

January 17, 2018
Severe eczema, also known as atopic dermatitis, is a chronic inflammatory skin condition that is driven by an allergic reaction. In their latest study, researchers at La Jolla Institute reveal an important player that promotes ...

Who might benefit from immunotherapy? New study suggests possible marker

January 16, 2018
While immunotherapy has made a big impact on cancer treatment, the fact remains that only about a quarter of patients respond to these treatments.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.