Scientists explain how memories stick together

April 16, 2014, Salk Institute
The hippocampus is a region of the brain largely responsible for memory formation. Credit: Salk Institute

Scientists at the Salk Institute have created a new model of memory that explains how neurons retain select memories a few hours after an event.

This new framework provides a more complete picture of how memory works, which can inform research into disorders liked Parkinson's, Alzheimer's, post-traumatic stress and learning disabilities.

"Previous models of memory were based on fast activity patterns," says Terry Sejnowski, holder of Salk's Francis Crick Chair and a Howard Hughes Medical Institute Investigator. "Our of memory makes it possible to integrate experiences over hours rather than moments."

Over the past few decades, neuroscientists have revealed much about how long-term memories are stored. For significant events—for example, being bit by a dog—a number of proteins are quickly made in activated brain cells to create the new memories. Some of these proteins linger for a few hours at specific places on specific neurons before breaking down.

This series of biochemical events allow us to remember important details about that event—such as, in the case of the dog bite, which dog, where it was located, if it required an emergency room visit, and so on.

One problem scientists have had with modeling memory storage is explaining why only selective details and not everything in that 1-2 hour window is strongly remembered. By incorporating data from previous literature, Sejnowski and first author Cian O'Donnell, a Salk postdoctoral researcher, developed a model that bridges findings from both molecular and systems observations of memory to explain how this 1-2 hour memory window works. The work is detailed in the latest issue of Neuron.

Using computational modeling, O'Donnell and Sejnowski show that, despite the proteins being available to a number of neurons in a given circuit, memories are retained when subsequent events activate the same neurons as the original event. The scientists found that the spatial positioning of proteins at both specific neurons and at specific areas around these neurons predicts which memories are recorded. This spatial patterning framework successfully predicts memory retention as a mathematical function of time and location overlap.

"One thing this study does is link what's happing in memory formation at the cellular level to the systems level," says O'Donnell. "That the time window is important was already established; we worked out how the content could also determine whether memories were remembered or not. We prove that a set of ideas are consistent and sufficient to explain something in the real world."

The new model also provides a potential framework for understanding how generalizations from memories are processed during dreams.

While much is still unknown about sleep, research suggests that important memories from the day are often cycled through the brain, shuttled from temporary storage in the hippocampus to more long-term storage in the cortex. Researchers observed most of this in non-dreaming sleep. Little is known about if and how memory packaging or consolidation is done during dreams. However, O'Donnell and Sejnowski's model suggests that some does happen during dreams.

"During sleep there's a reorganizing of memory—you strengthen some memories and lose ones you don't need anymore," says O'Donnell. "In addition, people learn abstractions as they sleep, but there was no idea how generalization processes happen at a neural level."

By applying their theoretical findings on overlap activity within the 1-2 hour window, they came up with a theoretical model for how the abstraction process might work during sleep.

Explore further: Memory accuracy and strength can be manipulated during sleep

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russell_russell
not rated yet Apr 16, 2014
"One thing this study does is link what's happening in memory formation at the cellular level to the systems level," says O'Donnell.

Knowing exactly where and how memory is stored at the molecular level reveals all the roles sleep serves in memory storage as well as explaining any formation of all memory. All processes stem from storage in any neurological modeling - if one asserts that without any kind of molecular storage method no correct neurological modeling is possible.

The missing molecular link linking to any level above the molecular link is known yet is never included in popular science reporting of any neurological research.

As if this is a spoiler alert for all other neurological research that follows from how and where storage occurs. As if there is no difference between the entertainment value of popular science reporting and research focused only on alleviating all human disease, pathologies and suffering.

How long can a myth of a missing narrative be used?

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