ATS: AMG 157 offers relief for allergen-induced asthma

May 21, 2014
ATS: AMG 157 offers relief for allergen-induced asthma

(HealthDay)—Twelve weeks of the novel AMG 157 antibody treatment may benefit patients with poorly controlled asthma, according to a study published online May 20 in the New England Journal of Medicine. This research was published to coincide with the annual meeting of the American Thoracic Society, held from May 16 to 21 in San Diego.

Gail M. Gauvreau, Ph.D., from McMaster University in Hamilton, Canada, and colleagues randomized 31 patients with mild allergies to receive three monthly doses of AMG 157 (700 mg) or placebo intravenously. Allergen challenges were conducted on days 42 and 84. Maximum percentage decrease in the forced expiratory volume in one second (FEV1) was measured.

The researchers found that AMG 157 cut most measures of allergen-induced early and late asthmatic responses. Compared to the , during the late response, FEV1 was 34 percent smaller in the AMG-157 group on day 42 (P = 0.09) and 45.9 percent smaller on day 84 (P = 0.02). There were also significant decreases in levels of blood and sputum eosinophils before and after the allergen challenge with AMG 157. There were no serious adverse events reported.

"Treatment with AMG 157 reduced allergen-induced bronchoconstriction and indexes of airway inflammation before and after allergen challenge," the authors write.

The study was funded by Amgen, the manufacturer of AMG 157.

Explore further: New drug significantly lowers bad cholesterol

More information: Abstract
Full Text
Editorial
More Information

Related Stories

New drug significantly lowers bad cholesterol

November 6, 2012
For many people with high cholesterol, statins serve as the first line of treatment. However, some patients are unable to effectively reduce their low-density lipoprotein cholesterol (LDL cholesterol) or "bad cholesterol" ...

Researchers discover new potential antibody treatment for asthma

May 20, 2014
Researchers at St. Joseph's Healthcare Hamilton and McMaster University have successfully tested an antibody that can improve the quality of life for individuals with asthma by relieving inflammation in the lungs. The research ...

Monthly shot lowers cholesterol 66 percent: study

March 26, 2012
A monthly injection of an experimental drug made by the US biotech firm Amgen reduced patients' cholesterol by up to 66 percent, according to a small study described at a US cardiology conference.

Addition of tiotropium effective in poorly controlled asthma

September 4, 2012
(HealthDay)—For patients with poorly controlled asthma, the addition of tiotropium to standard therapy is beneficial, according to a study published online Sept. 3 in the New England Journal of Medicine to coincide with ...

Race linked to childhood food allergies, not environmental allergies

February 23, 2013
Research conducted at Henry Ford Hospital shows that race and possibly genetics play a role in children's sensitivity to developing allergies.

Recommended for you

Targeting 'broken' metabolism in immune cells reduces inflammatory disease

July 12, 2017
The team, led by researchers at Imperial College London, Queen Mary University of London and Ergon Pharmaceuticals, believes the approach could offer new hope in the treatment of inflammatory conditions like arthritis, autoimmune ...

A perturbed skin microbiome can be 'contagious' and promote inflammation, study finds

June 29, 2017
Even in healthy individuals, the skin plays host to a menagerie of bacteria, fungi and viruses. Growing scientific evidence suggests that this lively community, collectively known as the skin microbiome, serves an important ...

Inflammatory bowel disease: Scientists zoom in on genetic culprits

June 28, 2017
Scientists have closed in on specific genes responsible for Inflammatory Bowel Disease (IBD) from a list of over 600 genes that were suspects for the disease. The team from the Wellcome Trust Sanger Institute and their collaborators ...

Trials show unique stem cells a potential asthma treatment

June 28, 2017
A study led by scientists at Monash University has shown that a new therapy developed through stem cell technology holds promise as a treatment for chronic asthma.

Researchers find piece in inflammatory disease puzzle

May 23, 2017
Inflammation is the process by which the body responds to injury or infection but when this process becomes out of control it can cause disease. Monash Biomedicine Discovery Institute (BDI) researchers, in collaboration with ...

Researchers reveal potential target for the treatment of skin inflammation in eczema and psoriasis

May 22, 2017
Superficially, psoriasis and atopic dermatitis may appear similar but their commonalities are only skin deep. Atopic dermatitis, also known as eczema, is primarily driven by an allergic reaction, while psoriasis is considered ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.