ATS: AMG 157 offers relief for allergen-induced asthma

May 21, 2014
ATS: AMG 157 offers relief for allergen-induced asthma

(HealthDay)—Twelve weeks of the novel AMG 157 antibody treatment may benefit patients with poorly controlled asthma, according to a study published online May 20 in the New England Journal of Medicine. This research was published to coincide with the annual meeting of the American Thoracic Society, held from May 16 to 21 in San Diego.

Gail M. Gauvreau, Ph.D., from McMaster University in Hamilton, Canada, and colleagues randomized 31 patients with mild allergies to receive three monthly doses of AMG 157 (700 mg) or placebo intravenously. Allergen challenges were conducted on days 42 and 84. Maximum percentage decrease in the forced expiratory volume in one second (FEV1) was measured.

The researchers found that AMG 157 cut most measures of allergen-induced early and late asthmatic responses. Compared to the , during the late response, FEV1 was 34 percent smaller in the AMG-157 group on day 42 (P = 0.09) and 45.9 percent smaller on day 84 (P = 0.02). There were also significant decreases in levels of blood and sputum eosinophils before and after the allergen challenge with AMG 157. There were no serious adverse events reported.

"Treatment with AMG 157 reduced allergen-induced bronchoconstriction and indexes of airway inflammation before and after allergen challenge," the authors write.

The study was funded by Amgen, the manufacturer of AMG 157.

Explore further: New drug significantly lowers bad cholesterol

More information: Abstract
Full Text
Editorial
More Information

Related Stories

New drug significantly lowers bad cholesterol

November 6, 2012
For many people with high cholesterol, statins serve as the first line of treatment. However, some patients are unable to effectively reduce their low-density lipoprotein cholesterol (LDL cholesterol) or "bad cholesterol" ...

Researchers discover new potential antibody treatment for asthma

May 20, 2014
Researchers at St. Joseph's Healthcare Hamilton and McMaster University have successfully tested an antibody that can improve the quality of life for individuals with asthma by relieving inflammation in the lungs. The research ...

Monthly shot lowers cholesterol 66 percent: study

March 26, 2012
A monthly injection of an experimental drug made by the US biotech firm Amgen reduced patients' cholesterol by up to 66 percent, according to a small study described at a US cardiology conference.

Addition of tiotropium effective in poorly controlled asthma

September 4, 2012
(HealthDay)—For patients with poorly controlled asthma, the addition of tiotropium to standard therapy is beneficial, according to a study published online Sept. 3 in the New England Journal of Medicine to coincide with ...

Race linked to childhood food allergies, not environmental allergies

February 23, 2013
Research conducted at Henry Ford Hospital shows that race and possibly genetics play a role in children's sensitivity to developing allergies.

Recommended for you

Chronic inflammation causes loss of muscle mass during aging

January 12, 2018
People start losing muscle mass at the age of 40—about some 10 percent of the total muscle mass for each 10-year period, which may lead to fall-related injuries, slowing metabolism and reduced quality of life. Today, very ...

Breathing exercises help asthma patients with quality of life

December 13, 2017
A study led by the University of Southampton has found that people who continue to get problems from their asthma, despite receiving standard treatment, experience an improved quality of life when they are taught breathing ...

Study highlights the need for research into prevention of inflammatory bowel disease

December 7, 2017
Countries in Africa, Asia, the Middle East and South America have seen a rise in incidence of inflammatory bowel disease as they have become increasingly industrialised and westernised, a new study has found.

Air pollution can increase asthma risk in adults, even at low levels

November 24, 2017
Living close to a busy road can be bad for your respiratory health if you are middle aged, new Australian research has found.

Evidence found of oral bacteria contributing to bowel disorders

October 20, 2017
(Medical Xpress)—An international team of researchers has found evidence that suggests certain types of oral bacteria may cause or exacerbate bowel disorders. In their paper published in the journal Science, the group describes ...

New compound discovered in fight against inflammatory disease

September 22, 2017
A 10-year study by University of Manchester scientists for a new chemical compound that is able to block a key component in inflammatory illness has ended in success.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.