Researchers develop genetic profile of the Netherlands

June 30, 2014 by Annette Kik, Centrum Wiskunde & Informatica
Researchers develop genetic profile of the Netherlands

In a large-scale research project under supervision of University Medical Center Groningen (UMCG) researchers have developed a genetic profile of the Netherlands. The researchers have mapped the DNA sequences of 250 family trios, consisting of two parents and one child, across the Netherlands. It is the first time that the genes of healthy persons have been analyzed in this number and with this precision.

The research is published in Nature Genetics on 29 June 2014.

"This profile allows for connecting to illnesses," says project leader Cisca Wijmenga (UMCG). "The Genome of the Netherlands can greatly accelerate research into genes that play a key role in the development of chronical and age-related diseases. We can now focus specifically on the disease-causing genes. The Genome of the Netherlands provides a catalogue that shows which amount of DNA variation is tolerable, and which amound eventually causes a disease."

A noticeable result is that every participant in this research on average turned out to have twenty mutations that were thought to cause rare diseases, although the participants were perfectly healthy.

Faster Big Data algorithms developed by Alexander Schönhuth from the Centrum Wiskunde & Informatica (CWI) are the first to be able to analyze and compare full DNA sequences. 'Previous methods were too slow to use all elements in the data set,'says Schönhuth.

"There are good algorithms available to detect small and large variations, but middle-sized DNA differences were harder to find. No less than 98.4% of all variations our techniques found in this bandwidth were new and previously unknown."

Explore further: Researchers find genome sequencing can be used to identify severe intellectual disability

More information: Whole-genome sequence variation, population structure and demographic history of the Dutch population, Nature Genetics,

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not rated yet Jun 30, 2014
Re: "...every participant in this research on average turned out to have twenty mutations that were thought to cause rare diseases, although the participants were perfectly healthy."

If the "mutations" were directly linked to nutrient-dependent SNPs; altered intracellular thermodynamics of seemingly futile cycles of protein biosynthesis and degradation; and to pheromone-controlled reproduction via the metabolism of nutrients, it would become obvious that the amino acid substitutions, which differentiate the cell types of all individuals in all species are not mutations. Wouldn't it?

If so, the question of how mutations contribute to the organism-level thermoregulation required for species diversity could be answered correctly by saying: mutations perturb protein folding; they do not lead to natural selection and the evolution of biodiversity.
not rated yet Jun 30, 2014

"An environmental drive evolved from that of nutrient ingestion in unicellular organisms to that of pheromone-controlled socialization in insects. In mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on pheromone-controlled sexual behavior in nutrientdependent reproductively fit individuals across species of vertebrates."

ISHE 2013 video

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