How an individual's immune system responds to psychological stressors

June 24, 2014 by Shelley Littin
In Reed's lab, couples participating in her study induce an immune system stress response in their bodies by discussing an issue of contention in their relationship. Credit: Rebecca Reed

(Medical Xpress)—When we fight with a romantic partner and our stress levels rise, we know our fear is based on emotion and that the only real threat we face is the possibility of a wounded heart.

But to our bodies, the threat can seem as real as an approaching lion, which sets into motion a response that could have long-term impacts on our health.

Rebecca Reed, a doctoral candidate in family studies and human development in the University of Arizona College of Agriculture and Life Sciences, is studying how a couple's recovery from an argument affects their immune systems and overall health. Her research findings could apply to any close relationship where there is emotional involvement between partners, including parent-child relationships, siblings, friendships and co-workers.

Reed's research is at the intersection of health, close relationships and emotion regulation. Categorized as "psychoneuroimmunology," it's a study of how psychology – in this case, people's psychological response to a stressful interaction with an intimate partner – activates neurons in the brain to ultimately affect functioning of the .

When a person perceives a threat, his or her body mounts an almost instantaneous stress response, releasing hormones and immune biomarkers that issue a "call to arms" to the body's in case the person is attacked and injured, Reed explained.

It's important that decreases after a stressful incident, she said, because a heightened for an extended period of time is stressful on the body's systems and strongly correlates with a number of chronic illnesses, including cardiovascular disease, diabetes, obesity and even some cancers.

The Lion in Your Lover's Eyes
How do interactions with an intimate partner affect your overall physical health? "None of us exist in a vacuum," said Reed, explaining that close relationship interactions have significant impacts on personal health.

Though we hopefully know the difference, our bodies' immune responses don't differentiate between a peeved lover and a predatory lion. When confronted with a psychological stressor, such as a tense discussion or giving a public speech, our immune systems respond the same as they would for an impending physical attack.

"When we give a public speech or have an argument with a loved one, our immune system responds to that," Reed said. "But a really critical part of the process is to recover afterwards and to decrease your immune response when it's no longer needed."

Essentially, too much psychological stress literally can make you sick, while the ability to recover from stressful situations may decrease risk of chronic illness and improve overall health and quality of life.

Reed's research project, Couples' Healthy Immune and Emotions Study, is investigating the way couples' immune systems respond to and recover from emotionally stressful encounters.

Reed studies couples for five days, during which the participants collect swabs of their own saliva four times each day and keep a diary of their daily activities and associated emotions, which Reed uses to map out the couples' emotions and stressors during the study days.

Reed measures variations in one immune biomarker called Interleukin 6, or IL-6, in the individuals' saliva. "Higher IL-6 is a proxy for a more activated immune response," she said. "It's one of the most studied biomarkers in our field because it's very sensitive to psychological stimuli."

"Biomarkers like IL-6 have a diurnal rhythm, meaning that they change over the course of the day," Reed explained. "Days one and two are baseline days, where we capture the normative diurnal rhythm. On day three the couples come into the lab and experience a controlled stressor, in which they talk about an area of disagreement in their relationship. That stressor is meant to activate their immune system. Then we capture the recovery phase during days 4 and 5."

The project examines how partners experience stressors and how they recover both emotionally and immunologically, she explained. "Part of the purpose is to understand how to reliably measure immune recovery with psychological stressors. We know that acute stressors may induce 24 hours later, but we don't know how long it takes for individuals to recover, and what interpersonal processes may facilitate faster recovery."

Reed also is looking at interpersonal dynamics between couples that may aid immune recovery from an argument or other sources of psychological stress.

She believes that one way to turn off the immune response may be for couples to foster effective interpersonal communication with attention to each other's emotional states. This could help them not only emotionally recover from stressors, but also immunologically recover, she said.

"None of us exist in a vacuum," Reed explained. "Close relationships have very significant effects on health. Our research is moving beyond the individual, to study people within their social systems."

Explore further: Breakthrough in understanding immune response

More information: Reed is looking for couples to participate in her five-day study through July. Nonsmoking couples who have been together for more than six months are older than 21 can contact her to volunteer.

Related Stories

Breakthrough in understanding immune response

June 23, 2014
(Medical Xpress)—A team of researchers led by Professor Mark Lindsay from our Department of Pharmacy & Pharmacology has made a breakthrough in identifying the genes that regulate the immune response.

Immune response affects sleep and memory

June 12, 2014
Sickness-induced insomnia is common because of link between brain and immune system

Disruption of VISTA plays an important role in regulating immune response

April 7, 2014
Researchers at the Geisel School of Medicine at Dartmouth have found that the body's immune system response was enhanced when they disrupted VISTA, a protein that prevents the immune system from overreacting. Understanding ...

Childhood abuse leads to poor adult health

November 13, 2012
The psychological scars of childhood abuse can last well into adulthood. New research from Concordia University shows the harm can have longterm negative physical effects, as well as emotional ones.

Scientists unravel how herpesviruses fight against our immune system

June 6, 2014
Pathogens entering our body only remain unnoticed for a short period. Within minutes our immune cells detect the invader and trigger an immune response. However, some viruses have developed strategies to avoid detection and ...

High family stress can impact a child's immune system

February 19, 2014
High family stress can lead to the child's immune system being affected, as a research group at the School of Health Sciences at Jönköping University and the Faculty of Health Sciences at Linköping University in Sweden ...

Recommended for you

Should I stay or should I leave? Untangling what goes on when a relationship is being questioned

August 17, 2017
Knowing whether to stay in or leave a romantic relationship is often an agonizing experience and that ambivalence can have negative consequences for health and well-being.

Kids learn moral lessons more effectively from stories with humans than human-like animals

August 17, 2017
A study by researchers at the Ontario Institute for Studies in Education (OISE) at the University of Toronto found that four to six-year-olds shared more after listening to books with human characters than books with anthropomorphic ...

History of stress increases miscarriage risk, says new review

August 17, 2017
A history of exposure to psychological stress can increase the risk of miscarriage by upto 42 per cent, according to a new review.

Study finds children pay close attention to potentially threatening information, avoid eye contact when anxious

August 17, 2017
We spend a lot of time looking at the eyes of others for social cues – it helps us understand a person's emotions, and make decisions about how to respond to them. We also know that adults avoid eye contact when anxious. ...

Communicating in a foreign language takes emotion out of decision making

August 16, 2017
If you could save the lives of five people by pushing another bystander in front of a train to his death, would you do it? And should it make any difference if that choice is presented in a language you speak, but isn't your ...

Precision medicine opens the door to scientific wellness preventive approaches to suicide

August 15, 2017
Researchers have developed a more precise way of diagnosing suicide risk, by developing blood tests that work in everybody, as well as more personalized blood tests for different subtypes of suicidality that they have newly ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.